{"created":"2023-07-27T06:56:11.876445+00:00","id":52949,"links":{},"metadata":{"_buckets":{"deposit":"c8cb1ca2-88ae-4d0a-b4c8-7c27a2530595"},"_deposit":{"created_by":18,"id":"52949","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52949"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052949","sets":["2812:2813:2817"]},"author_link":["23926","22166"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胃癌腹膜播種は高度の浸潤能と線維化を伴い化学療法抵抗性を示す。今回、新規微小管重合阻害剤であるエリブリンが胃がんの進展やEMT様変化を抑制するか検討すると同時に、5FUとの併用効果についても検討した。\nvitroでは、エリブリンは低濃度で胃癌細胞株MKN45の増殖とEMT様変化を抑制し、5FUとの相乗効果を認めた。vivoでは、マウスヒト胃癌細胞移植腫瘍（MKN45 + HPMC ヒト腹膜中皮細胞）の増殖と線維化を抑制した。以上より、エリブリンは胃癌腹膜播種の新しい治療戦略ツールとなりうる。","subitem_description_type":"Abstract"},{"subitem_description":"Peritoneal dissemination of gastric cancer is characterized by aggressive invasion, extensive stromal fibrosis, and resulting drug-resistant tumors. We examined whether eribulin, which is a newly microtubule dynamics inhibitor, could inhibit progression and EMT changes in gastric cancer and act synergistically with 5FU. Eribulin significantly suppressed gastric cancer cell proliferation, as well as EMT changes in MKN45 gastric cancer cells and HPMCs induced by their interaction in vitro. EMT inhibition by eribulin was observed at much lower concentrations than its IC50 and resulted, at least partly, from downregulation of TGF-β/Smad signaling by interruption of Smad2 phosphorylation. Eribulin also suppressed tumor progression and fibrosis in a mouse fibrotic tumor xenograft model. Furthermore, its administration with 5FU brought about synergistic antitumor effects. Eribulin demonstrates the potential to be a key treatment for peritoneal dissemination of gastric cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K21015, 研究期間(年度):2015-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「新規微小管作用薬による胃癌腹膜播種線維化抑制についての実験的検討」研究成果報告書　課題番号15K21015\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K21015/15K21015seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059235","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90642356"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90642356","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K21015/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K21015/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K21015/15K21015seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K21015/15K21015seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"ME-PR-TSUKADA-T-kaken 2017-6p.pdf","filesize":[{"value":"356.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TSUKADA-T-kaken 2017-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52949/files/ME-PR-TSUKADA-T-kaken 2017-6p.pdf"},"version_id":"7222a629-4988-4058-915d-b44f50af9b13"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規微小管作用薬による胃癌腹膜播種線維化抑制についての実験的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規微小管作用薬による胃癌腹膜播種線維化抑制についての実験的検討"},{"subitem_title":"Effect of eribulin, a new microtubule dynamics inhibitor, for tumor progression and fibrosis in peritoneal dissemination of gastric cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"52949","relation_version_is_last":true,"title":["新規微小管作用薬による胃癌腹膜播種線維化抑制についての実験的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:24.898991+00:00"}