{"created":"2023-07-27T06:56:12.056548+00:00","id":52953,"links":{},"metadata":{"_buckets":{"deposit":"00248ca9-a7d1-4c6d-a102-b270e4430783"},"_deposit":{"created_by":18,"id":"52953","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52953"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052953","sets":["2812:2813:2818"]},"author_link":["95212","25218"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウスにおいて高容量の抗原を経静脈投与することで血中抗原が胸腺樹状細胞により抗原提示され胸腺由来の抗原特異的T細胞を誘導し、さらにIL-2-IL-2抗体の免疫複合体（以下IL-2IC）を投与することでこれらの抗原特異的T細胞は効率的に増幅することができることが報告されている。これらの結果に基づき、我々は以下のような結果が得られた。\n経静脈的に抗原を投与しさらにIL-2ICを投与することで抗原特異的制御性T細胞を効果的に誘導増幅させることができた。それらの細胞群はCCR2依存性に抗原投与部位に集積することが観察され、さらに集積した制御性T細胞は局所の炎症に関与していた。","subitem_description_type":"Abstract"},{"subitem_description":"It is reported that a combined i.v. administration of antigen and IL-2-anti-IL-2 Ab immune complexes (IL-2 ICs) efficiently expands antigen-specific Treg cells in the thymus and induces their migration into peripheral blood. In this study, we explored that the expanded antigen-specific Treg cells rapidly move into the antigen injected site in CCR2 dependent manner. Moreover, prior treatment with antigen and IL-2 ICs enhanced antigen-specific Treg-cell migration and inhibited delayed type hypersensitivity (DTH) reactions. Thus, the treatment with Ag and IL-2 ICs can efficiently expand Ag-specific Treg cells with the capacity to migrate and reduce localized immune responses.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26860748, 研究期間(年度):2014-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胸腺由来制御性T細胞のin vivoでの誘導による免疫制御の基礎的検討」課題番号26860748\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26860748/26860748seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059239","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10623655"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10623655","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26860748/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26860748/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26860748/26860748seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26860748/26860748seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"ME-PR-HAMANO-R-kaken 2016-4p.pdf","filesize":[{"value":"106.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HAMANO-R-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52953/files/ME-PR-HAMANO-R-kaken 2016-4p.pdf"},"version_id":"6e9de5cd-6934-4eb1-b179-6e5f9d2c783a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胸腺由来制御性T細胞のin vivoでの誘導による免疫制御の基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胸腺由来制御性T細胞のin vivoでの誘導による免疫制御の基礎的検討"},{"subitem_title":"A basic study about the immune regulation by thymus-derived regulatory T cells induced in vivo","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-05"},"publish_date":"2020-11-05","publish_status":"0","recid":"52953","relation_version_is_last":true,"title":["胸腺由来制御性T細胞のin vivoでの誘導による免疫制御の基礎的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:53:04.329119+00:00"}