{"created":"2023-07-27T06:56:12.191921+00:00","id":52956,"links":{},"metadata":{"_buckets":{"deposit":"e503b443-33d3-44d6-afff-3803a7e4f003"},"_deposit":{"created_by":18,"id":"52956","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52956"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052956","sets":["2812:2813:2816"]},"author_link":["95066","2155"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ストレスや不安にかかわる大脳辺縁系と覚醒系の相互関係を神経科学的に解明するために研究を行なった。ノンレム睡眠のマウスに分界条床核のGABA作動性ニューロンを光遺伝学的に刺激すると直ちに覚醒に移行した。この作用はオレキシン拮抗薬によって阻害されなかった。一方、化学遺伝学的にこれらのニューロンを興奮させると覚醒時間が延びたが、この作用はオレキシン受容体拮抗薬によって阻害された。一方、オレキシンの下流における青斑核のノルアドレナリンニューロンが扁桃体外側部を介して恐怖行動を増強し、汎化に関与することを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"We found that acute optogenetic excitation of GABA neurons in the BNST during non-rapid eye movement (NREM) sleep in mice resulted in immediate transition to a wakefulness state without the function of orexins. Prolonged excitation of GABABNST neurons by a chemogenetic method evoked a longer-lasting, sustained wakefulness state, which was abolished by pre-administration of a dual orexin receptor antagonist. We also found that when the orexin→NA→amygdala circuit was artificially activated, fear-related behavior increased in a similar but distinct from the training context. Increased activation of these circuits enhanced the fear response in otherwise neutral situation. Conditions that naturally activate orexin neurons, such as fasting, could result in an orexin-dependent shift to a ‘vigilance’ state and alter the selection of a behavioral response to avoid and handle environmental threats.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H03122, 研究期間(年度):2015-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ストレスや不安が過覚醒をうむ神経科学的機構の解明」課題番号15H03122\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15H03122/15H03122seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"筑波大学 / 金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059242","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60251055"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60251055","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H03122/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H03122/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15H03122/15H03122seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15H03122/15H03122seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"ME-PR-SAKURAI-T-kaken 2018-6p.pdf","filesize":[{"value":"612.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAKURAI-T-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52956/files/ME-PR-SAKURAI-T-kaken 2018-6p.pdf"},"version_id":"45909ddf-fb5e-4e1b-988c-bcf091a4c8c1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレスや不安が過覚醒をうむ神経科学的機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレスや不安が過覚醒をうむ神経科学的機構の解明"},{"subitem_title":"Neuronal mechanisms that regulate hyper-arousal in response to stress and anxiety","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"52956","relation_version_is_last":true,"title":["ストレスや不安が過覚醒をうむ神経科学的機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:55:56.666770+00:00"}