{"created":"2023-07-27T06:56:12.326168+00:00","id":52959,"links":{},"metadata":{"_buckets":{"deposit":"32f6b75f-2336-4335-80d8-906e7685ea7e"},"_deposit":{"created_by":18,"id":"52959","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52959"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052959","sets":["2812:2813:2818"]},"author_link":["24301","2699"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"子宮内膜症性卵巣嚢胞から発生する癌化にはp53の不活化、KRAS遺伝子活性化の2 hitに加え、c-mycの活性化が必要であることが示唆された。bcl2、PIK3CA、phospho-Aktの関与については、これらの下流でいずれもmycが活性化されており、myc経路に集約される可能性があると思われた。","subitem_description_type":"Abstract"},{"subitem_description":"Ｍalignant transformation of endometriotic epithelial cells required overexpression of c-myc or phospho-Akt or mutation of PIK3CA in addition to dysfunctional p53 and mutated KRAS. Since overexpresison of phospho-Akt or mutation of PIK3CA lead to activate c-Myc by its phosphorylation, c-Myc activation in ovarian endometrioma might play a key role in transformation in the presence of dysfunctional p53 and activated ERK pathway.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26861317, 研究期間(年度):2014-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「子宮内膜症からの多段階発癌モデルの作成」課題番号26861317\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861317/26861317seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059245","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80565416"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80565416","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861317/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861317/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861317/26861317seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861317/26861317seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"HO-PR-BONO-Y-kaken 2016-4p.pdf","filesize":[{"value":"207.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-BONO-Y-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52959/files/HO-PR-BONO-Y-kaken 2016-4p.pdf"},"version_id":"62ae48d2-0d88-4957-bcc4-1abfd38a21d8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"子宮内膜症からの多段階発癌モデルの作成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮内膜症からの多段階発癌モデルの作成"},{"subitem_title":"Creation of the model of multistep carcinogenesis derived from ovarian endometrioma by introducing defined genetic elements","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-05"},"publish_date":"2020-11-05","publish_status":"0","recid":"52959","relation_version_is_last":true,"title":["子宮内膜症からの多段階発癌モデルの作成"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:53:11.280490+00:00"}