{"created":"2023-07-27T06:56:12.875949+00:00","id":52971,"links":{},"metadata":{"_buckets":{"deposit":"d9b66bd9-6d11-43d9-a517-9579760e7f7b"},"_deposit":{"created_by":18,"id":"52971","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52971"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052971","sets":["2812:2813:2817"]},"author_link":["94593","94588"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-08-28 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kokusho, Ryuhei"}],"nameIdentifiers":[{"nameIdentifier":"94593","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90756537","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90756537"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"バキュロウイルスは全身感染性の昆虫ウイルスで、actin rearrangement-inducing factor 1 遺伝子（arif-1）により宿主体内における感染拡大効率を飛躍的に向上させているが、その詳細な分子メカニズムは不明であった。本研究では、ARIF-1に様々な変異を導入することで、ARIF-1の機能に重要なアミノ酸領域を同定した。また、感染組織の詳細な観察から、これまで想定されていなかった新規の感染ルートを発見し、ARIF-1が新規感染ルートからの感染に必須な因子であることを突き止めた。","subitem_description_type":"Abstract"},{"subitem_description":"Baculoviruses are insect viruses that establish systemic infection in the body of host larvae. Previously we found that viral actin rearrangement-inducing factor 1 gene (arif-1) dramatically enhances systemic infection, but its molecular mechanism remains unknown. In this study, we introduced several mutations in arif-1 and identified amino acid regions responsible for its function. In addition, detailed observation of infected tissues revealed the previously unknown infection route that required ARIF-1.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H06155, 研究期間(年度):2015-08-28 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「バキュロウイルスの全身感染効率を規定する新たな分子メカニズムの解明」研究成果報告書　課題番号15H06155\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15H06155/15H06155seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域生命理工学系 / 東京大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059257","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90756537"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90756537","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H06155/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H06155/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15H06155/15H06155seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15H06155/15H06155seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"國生, 龍平"}],"nameIdentifiers":[{"nameIdentifier":"94588","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90756537","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90756537"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-10"}],"displaytype":"detail","filename":"SC-PR-KOKUSHO-R-kaken 2017-4p.pdf","filesize":[{"value":"466.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC-PR-KOKUSHO-R-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52971/files/SC-PR-KOKUSHO-R-kaken 2017-4p.pdf"},"version_id":"12bb4908-019d-4d5d-a780-51cd5df0442f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"バキュロウイルスの全身感染効率を規定する新たな分子メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バキュロウイルスの全身感染効率を規定する新たな分子メカニズムの解明"},{"subitem_title":"Investigation of the molecular mechanism underlying efficient systemic infection of the baculovirus","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-10"},"publish_date":"2020-09-10","publish_status":"0","recid":"52971","relation_version_is_last":true,"title":["バキュロウイルスの全身感染効率を規定する新たな分子メカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:40:27.899486+00:00"}