{"created":"2023-07-27T06:56:15.191871+00:00","id":53037,"links":{},"metadata":{"_buckets":{"deposit":"73b4c564-a753-45ac-afbf-2d6da307fd89"},"_deposit":{"created_by":18,"id":"53037","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53037"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053037","sets":["2812:2813:3929"]},"author_link":["94613","27295"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2016-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"異物応答性核内受容体 PXR は、肝臓でのエネルギー代謝制御における機能的役割が示唆されているが、ヒトにおいてその分子機構は明らかではない。本研究では、ヒト肝癌細胞において薬剤処置により活性化した PXR が細胞内シグナル因子 SGK2 と共に、脂肪酸のβ酸化関連酵素遺伝子 CPT1A および ACSL1 の発現量を増加させることを見出した。さらに、CPT1A 遺伝子上流領域に薬剤処置依存的な PXR および SGK2 の結合サイトを同定した。これらの成果より、PXR は SGK2 と協調的に作用して脂肪酸のβ酸化を制御する新たな可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"Xenobiotic-sensing nuclear receptor, pregnane X receptor (PXR) may play a functional role in hepatic energy metabolism. However, the molecular mechanism remains unknown in humans. In this study, we demonstrated that drug-activated PXR increased mRNA expression of fatty acid β-oxidation-related genes, including CPT1A and ACSL1 in human hepatocellular carcinoma cells. PXR required serum/glucocorticoid regulated kinase 2 (SGK2) in the regulation. Furthermore, we identified PXR/SGK2 binding site within the 5’ upstream region of CPT1A gene in a drug-dependent manner. These results suggest the possibility that PXR utilizes SGK2 to regulate fatty acid β-oxidation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K21055, 研究期間(年度):2016-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「薬剤誘発性糖尿病におけるPXR/SGK2 シグナル経路の機能的役割の解明」研究成果報告書　課題番号16K21055\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K21055/16K21055seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"東京都医学総合研究所 / 金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_full_name_35":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"27295","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60756609","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60756609"}],"names":[{"name":"齊藤, 紗希"}]}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059321","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60756609"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60756609","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K21055/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K21055/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K21055/16K21055seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K21055/16K21055seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"後藤, 紗希"}],"nameIdentifiers":[{"nameIdentifier":"94613","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60756609","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60756609"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-14"}],"displaytype":"detail","filename":"PH-PR-GOTOH-S-kaken 2020-7p.pdf","filesize":[{"value":"186.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-GOTOH-S-kaken 2020-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53037/files/PH-PR-GOTOH-S-kaken 2020-7p.pdf"},"version_id":"cdbf05f2-f438-4f8a-9a6b-ec46439e1ef6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬剤誘発性糖尿病におけるPXR/SGK2 シグナル経路の機能的役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬剤誘発性糖尿病におけるPXR/SGK2 シグナル経路の機能的役割の解明"},{"subitem_title":"Investigation of the role of PXR-SGK2 signaling in drug-induced diabetes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-14"},"publish_date":"2021-05-14","publish_status":"0","recid":"53037","relation_version_is_last":true,"title":["薬剤誘発性糖尿病におけるPXR/SGK2 シグナル経路の機能的役割の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:24:17.337487+00:00"}