{"created":"2023-07-27T06:56:16.496410+00:00","id":53068,"links":{},"metadata":{"_buckets":{"deposit":"255e84f2-8325-4b28-aa54-a54cee49d4cd"},"_deposit":{"created_by":18,"id":"53068","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53068"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053068","sets":["2812:2813:2816"]},"author_link":["258","84802"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生理活性脂質スフィンゴシン1-リン酸は血管内皮細胞のバリア機能を強化することにより血管透過性を抑制することが知られている。本研究において、内皮細胞に発現するスフィンゴシン1-リン酸2型受容体が、内皮型一酸化窒素合成酵素抑制を介して急性肺損傷時の血管バリア機能破綻に防御的に働くことが示された。以上の結果から、スフィンゴシン1-リン酸2型受容体が急性肺損傷の新しい治療標的となる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Sphingosine　1-phosphate (S1P) is a lysophospholipid mediator and plays an important role in the regulation of vascular barrier function. In this study, we found that S1P2 mediates the protection from acute lung injury possibly through inhibiting endothelial nitric oxide synthase, pointing to S1P2 as a promising novel target for treating acute lung injury.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K10970, 研究期間(年度):2015-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「急性肺損傷に関わるスフィンゴ脂質シグナリングの解明と新規治療戦略」課題番号15K10970\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K10970/15K10970seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"川崎医科大学 / 金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059352","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80293877"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80293877","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K10970/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K10970/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K10970/15K10970seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K10970/15K10970seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"ME-PR-OKAMOTO-Y-kaken 2018-6p.pdf","filesize":[{"value":"437.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OKAMOTO-Y-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53068/files/ME-PR-OKAMOTO-Y-kaken 2018-6p.pdf"},"version_id":"85bb7220-6078-4365-b34d-6e0c0ed09c61"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"急性肺損傷に関わるスフィンゴ脂質シグナリングの解明と新規治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"急性肺損傷に関わるスフィンゴ脂質シグナリングの解明と新規治療戦略"},{"subitem_title":"A novel strategy of acute lung injury: Targeting sphingolipid signaling","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"53068","relation_version_is_last":true,"title":["急性肺損傷に関わるスフィンゴ脂質シグナリングの解明と新規治療戦略"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:56:06.419307+00:00"}