{"created":"2023-07-27T06:56:17.216391+00:00","id":53086,"links":{},"metadata":{"_buckets":{"deposit":"f5114c76-074f-4026-aa70-4e2a862f1f8d"},"_deposit":{"created_by":18,"id":"53086","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53086"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053086","sets":["2812:2813:2815"]},"author_link":["85184","22560"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"関節リウマチ患者血中IgG においては、結合しているN結合型糖鎖のガラクトース欠損が知られている。近年TNFα 阻害薬治療により、糖鎖異常が正常パターンに戻ることが報告された。糖鎖は、抗体の受容体であるFcγ 受容体との相互作用や、補体結合作用において重要な働きをしている。我々は，IL-6 阻害薬投与症例およびDMARDs投与症例において，治療前後の血清を用いIgG を精製した。そして，MALDI-TOF MSを用いて血清IgG の糖鎖解析を行った。その結果，治療法に関わらず，治療後にはガラクトースが増加しているプロファイルがみられた。","subitem_description_type":"Abstract"},{"subitem_description":"N-glycosylation pattern of IgG in patients with rheumatoid arthritis is reduced galactosylation. This aberrant glycosylation improve after TNF-alfa blockade therapy. Glycosylation of IgG is important in effector function of IgG such as interaction with Fc receptor. We purify serum IgG in patients who recieved IL-6 blockade or DMARDs. And we performed glycan analysis using MALDI-TOF MS. The aberrant glycosylation of IgG improve after each therapy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K19572, 研究期間(年度):2015-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「関節リウマチにおける糖鎖制御機構の解明」課題番号15K19572\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K19572/15K19572seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059370","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10467110"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10467110","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K19572/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K19572/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K19572/15K19572seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K19572/15K19572seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-28"}],"displaytype":"detail","filename":"HO-PR-ITO-K-kaken 2019-4p.pdf","filesize":[{"value":"165.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-ITO-K-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53086/files/HO-PR-ITO-K-kaken 2019-4p.pdf"},"version_id":"4400e3df-bebc-46f6-9289-8af1a05d9506"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"関節リウマチにおける糖鎖制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"関節リウマチにおける糖鎖制御機構の解明"},{"subitem_title":"The mechanism of aberrant glycosylation in rheumatoid arthritis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-28"},"publish_date":"2020-09-28","publish_status":"0","recid":"53086","relation_version_is_last":true,"title":["関節リウマチにおける糖鎖制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:30:21.854340+00:00"}