{"created":"2023-07-27T06:56:17.396117+00:00","id":53090,"links":{},"metadata":{"_buckets":{"deposit":"c4df3a6c-4f28-4eb0-b46e-fe4630dfc4f1"},"_deposit":{"created_by":18,"id":"53090","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53090"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053090","sets":["2812:2813:2816"]},"author_link":["467","78917"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"全身型若年性特発性関節炎（s-JIA）および成人スティル病症例の血清サイトカインプロファイル解析およびNK細胞のIL-18応答性に関する経時的解析を行った。両疾患ともに血清IL-18濃度が異常高値を示し、IL-6優位群では関節炎症状が強く、IL-18優位群ではマクロファージ活性化症候群（MAS）の合併が多かった。NK細胞はs-JIAの急性期においてIL-18に対する応答性が低下するが、治療後血清IL-18濃度の低下に一致して反応性が回復した。抗体アレイによる網羅的発現プロファイル解析から、MASの発症にはIL-18/IFNγがMAS発症に重要な役割を果たしていることが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated serum cytokine profile in patients with systemic juvenile idiopathic arthritis (s-JIA) and adult onset Still’s disease (AOSD). Furthermore, we sequentially analyzed NK cell activation upon IL-18 in these patients from active phase to remisson. Serum IL-18 levels were extremely elevated in s-JIA and AOSD patients. IL-6 dominant subset was prone to arthritis, while IL-18 dominant subset was prone to develop macrophage activation syndrome (MAS). NK cell activation upon IL-18 was impaired in active phase and recovered after treatment as serum IL-18 levels decreased. Extensive cytokine profile analysis with antibody array revealed IL-18/IFNγ axis play a key role to develop MAS.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26461571, 研究期間(年度):2014-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「全身型若年性特発性関節炎の発症に関する分子免疫学的解析とその臨床応用」課題番号26461571\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461571/26461571seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059374","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10401902"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10401902","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26461571/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26461571/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461571/26461571seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461571/26461571seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"ME-PR-SHIMIZU-M-kaken 2018-4p.pdf","filesize":[{"value":"84.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHIMIZU-M-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53090/files/ME-PR-SHIMIZU-M-kaken 2018-4p.pdf"},"version_id":"a2f9a3b0-34c4-4e6e-bd37-6d9b55590338"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"全身型若年性特発性関節炎の発症に関する分子免疫学的解析とその臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身型若年性特発性関節炎の発症に関する分子免疫学的解析とその臨床応用"},{"subitem_title":"Molecular and immunological analysis to clarify the pathogenesis of systemic juvenile idiopathic arthritis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"53090","relation_version_is_last":true,"title":["全身型若年性特発性関節炎の発症に関する分子免疫学的解析とその臨床応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:56:17.306743+00:00"}