{"created":"2023-07-27T06:56:18.040240+00:00","id":53105,"links":{},"metadata":{"_buckets":{"deposit":"1b501dfc-7646-4fee-908f-419dd3888a10"},"_deposit":{"created_by":18,"id":"53105","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53105"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053105","sets":["2812:2813:2817"]},"author_link":["72554","265"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"VEGF－固定ステント長期留置モデルにおいて、ステント表面は新生内膜で完全に被覆されていた。また、ステント周囲には炎症細胞はわずかで、新規の平滑筋細胞の増殖を認めていることから、血管修復反応は終了していると考えられた。新生内膜の増殖の抑制効果については、既存の薬剤溶出性ステントと比較して新生内膜の増殖は有意に抑制されていた。短期モデルおいて、ステント表面はすでに新生内膜で被覆されていることが確認された。留置後早期に新生内膜の増殖を認め、抗血小板薬の内服期間の短縮化が期待されると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We developed VEGF-bound stents that may enable selective capture of EPCs followed by rapid endothelialization. Metallic stents were first coated with poly-(ethylene-co-vinyl alcohol), and then chemically bound with either VEGF. These stents were placed in porcine coronary arteries. Stent surface was evaluated by immunohistochemistry and by scanning electron microscope. VEGF-bound stents, small populations of KDR positive cells adhered to the stent struts. After long-term stenting, struts were fully covered with newly regenerated tissue. SEM images showed that the uniform tissue formed on struts was morphologically similar to native endothelium and was continuously connected with adjacent native endothelium. VEGF-bound stents provide highly selective capture of EPCs, followed by rapid formation of intact endothelium tissue at an early period of stenting. These results suggest that VEGF-bound stents could represent a promising therapeutic option for cardiovascular stenting.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26461105, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「内皮前駆細胞を流血中で捕捉・内皮化する新規ステントの開発と臨床応用」研究成果報告書　課題番号26461105\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461105/26461105seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059389","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70393238"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70393238","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26461105/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26461105/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461105/26461105seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461105/26461105seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-23"}],"displaytype":"detail","filename":"ME-PR-YAMAGISHI-M-kaken 2017-4p.pdf","filesize":[{"value":"301.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMAGISHI-M-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53105/files/ME-PR-YAMAGISHI-M-kaken 2017-4p.pdf"},"version_id":"a1fececb-ee92-42ea-a234-08272be3ed8b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"内皮前駆細胞を流血中で捕捉・内皮化する新規ステントの開発と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内皮前駆細胞を流血中で捕捉・内皮化する新規ステントの開発と臨床応用"},{"subitem_title":"Vascular endothelial growth factor-bound stents: application of in situ capture technology of circulating endothelial progenitor cells in porcine coronary model","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"53105","relation_version_is_last":true,"title":["内皮前駆細胞を流血中で捕捉・内皮化する新規ステントの開発と臨床応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:38.509942+00:00"}