{"created":"2023-07-27T06:56:18.999467+00:00","id":53129,"links":{},"metadata":{"_buckets":{"deposit":"69642881-e4da-417d-863e-b8bede4785ae"},"_deposit":{"created_by":18,"id":"53129","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53129"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053129","sets":["2812:2813:4085"]},"author_link":["76757","259"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2020-07-30 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The central circadian clock in the suprachiasmatic nucleus (SCN) of the hypothalamus is synchronized to the day-night cycle of the external world transmitted from the retina (light entrainment). Light information is first transmitted to the core cells, and then information is sent from the core to the shell, resulting in a phase shift of the entire SCN. The signal transduction mechanisms of core cells have been well studied. However, for light entrainment to be established, the shell, which has a large number of cells and large circadian oscillations, must also undergo a phase shift and become fixed, but this process is not known. We have obtained mice with dramatically altered light-entrainment ability by specific genetic manipulation of the SCN shell, and have analyzed it in detail.","subitem_description_type":"Abstract"},{"subitem_description":"視床下部視交叉上核（SCN）の中枢体内時計は、網膜から伝わる外界の昼夜サイクルに同調する（光同調）。SCNは背内側部（shell）と腹外側部（core）の二領域に大別される。光情報はまずcore細胞に伝えられ、coreからshellに情報が送られ、SCN全体の位相がシフトする。入力部・core細胞の情報伝達については研究が進んでいる。しかし光同調の成立には、細胞数も多く概日振動も大きいshellでも位相がシフトして固定される必要があるが、この過程は不明である。我々はSCN shellの特異的遺伝子操作により光同調能が劇的に変化したマウスを得たので、その詳細な解析を行った。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20K21498, 研究期間(年度):2020-07-30 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「中枢体内時計全体を包括した光同調メカニズムの統合的理解」課題番号20K21498\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K21498/20K21498seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059414","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20296552"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20296552","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K21498/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K21498/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K21498/20K21498seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K21498/20K21498seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-20"}],"displaytype":"detail","filename":"ME-PR-MIEDA-M-kaken 2022-7p.pdf","filesize":[{"value":"608.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIEDA-M-kaken 2022-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53129/files/ME-PR-MIEDA-M-kaken 2022-7p.pdf"},"version_id":"0922c554-a10d-4840-9e0c-09905ead1c80"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"中枢体内時計全体を包括した光同調メカニズムの統合的理解","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢体内時計全体を包括した光同調メカニズムの統合的理解"},{"subitem_title":"Integrated understanding of the light entrainment mechanism encompassing the entire central circadian clock","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-20"},"publish_date":"2023-02-20","publish_status":"0","recid":"53129","relation_version_is_last":true,"title":["中枢体内時計全体を包括した光同調メカニズムの統合的理解"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:27:32.218474+00:00"}