{"created":"2023-07-27T06:56:19.729359+00:00","id":53155,"links":{},"metadata":{"_buckets":{"deposit":"eb41a244-2181-4458-99d1-e16853c686da"},"_deposit":{"created_by":18,"id":"53155","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53155"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053155","sets":["2812:2813:2817"]},"author_link":["91848","274"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性骨髄性白血病(Chronic myelgenous leukemia; CML) 患者の生命予後はチロシンキナーゼ阻害剤 (TKI) の開発によって改善されたが，再発を克服するためCML幹細胞の治療が必要とされている．本研究ではCMLマウスモデルを用いてCML幹細胞の治療抵抗性メカニズムを解析した．その結果，幹細胞特異的なSmad3のSer208のリン酸化がCML幹細胞の自己複製能の維持に必須な役割を担うことを発見した．さらに，当該リン酸化はp38MAPKによって制御されており，CMLマウスモデルを用いた非臨床試験によってp38MAPK阻害剤を投与することで再発を軽減できることを証明した．","subitem_description_type":"Abstract"},{"subitem_description":"Although the discovery of tyrosine kinase inhibitors (TKIs) has been improved prognosis of chronic myelogenous leukemia (CML) patients, CML stem cells are responsible for the relapse of CML disease following TKI therapy. In this study, we found that the stem cell-specific phosphorylation of Smad3 at Ser208 residue plays an essential role for the maintenance of self-renewal capacity in CML stem cells in vivo. In addition, p38MAPK regulated the phosphorylation of Smad3 at Ser208. Indeed, we demonstrated that the administration of an inhibitor targeting p38MAPK significantly delayed the disease relapse of CML-affected mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26290038, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「CML幹細胞の未分化性を維持する幹細胞特異的Smad3リン酸化機構の解明」研究成果報告書　課題番号26290038\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26290038/26290038seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"広島大学 / 金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059440","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70372688"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70372688","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26290038/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26290038/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26290038/26290038seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26290038/26290038seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-23"}],"displaytype":"detail","filename":"ME-PR-NAKA-K-kaken 2017-6p.pdf","filesize":[{"value":"205.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKA-K-kaken 2017-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53155/files/ME-PR-NAKA-K-kaken 2017-6p.pdf"},"version_id":"b0d0890d-08c9-4405-87dd-b6466d176c13"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"CML幹細胞の未分化性を維持する幹細胞特異的Smad3リン酸化機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CML幹細胞の未分化性を維持する幹細胞特異的Smad3リン酸化機構の解明"},{"subitem_title":"Stem cell-specific phosphorylation of Smad3 for regulating self-renewal capacity in CML stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"53155","relation_version_is_last":true,"title":["CML幹細胞の未分化性を維持する幹細胞特異的Smad3リン酸化機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:33:28.256177+00:00"}