{"created":"2023-07-27T06:56:19.819547+00:00","id":53157,"links":{},"metadata":{"_buckets":{"deposit":"b11f890e-80e1-4d7b-97d6-ca33535381b2"},"_deposit":{"created_by":18,"id":"53157","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53157"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053157","sets":["2812:2813:2817"]},"author_link":["22657","70049"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アストロサイトは種々の脳病変において活性化し，様々な神経栄養因子を産生・分泌し，神経細胞保護・再生を促す一方，種々のサイトカインを産生・分泌し，炎症反応，脳浮腫を惹起する．また最終的にグリオーシスからグリア瘢痕を形成し，再生神経線維の伸長や移植神経細胞による神経回路再生を阻害する．本事業では、培養細胞モデルと実験動物モデルを用い，神経細胞障害および神経細胞移植におけるアストロサイトの活性化抑制による神経細胞保護効果を検討した．実験動物モデルでは，アストロサイトの活性化抑制による神経細胞保護効果を確認できなかったが，培養細胞モデルにおいては、同効果を確認した．","subitem_description_type":"Abstract"},{"subitem_description":"Astrocytes activate under various brain disorders followed by secretion of neurotrophic factors inducing neuronal cell protection and regenesis. On the other hand, they secrete cytokines aggrevating brain edema and inflammation, and form gliotic scar inhibiting neuronal regeneration. Using cell culture and animal experiments we investigated neuronal cell protection by inhibition of astrocytic activation. We demonstrated protective effects of neuronal cells by inhibition of astroctic activation in vitro, but not in vivo.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26560273, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「中枢神経障害および神経細胞移植におけるアストロサイト活性化の抑制効果」研究成果報告書　課題番号26560273\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26560273/26560273seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059442","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=40217675"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=40217675","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26560273/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26560273/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26560273/26560273seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26560273/26560273seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-23"}],"displaytype":"detail","filename":"ME-PR-NAKAGAWA-T-kaken 2017-4p.pdf","filesize":[{"value":"488.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAGAWA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53157/files/ME-PR-NAKAGAWA-T-kaken 2017-4p.pdf"},"version_id":"83f00b62-f9c1-4c75-b596-11cc24da1663"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"中枢神経障害および神経細胞移植におけるアストロサイト活性化の抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢神経障害および神経細胞移植におけるアストロサイト活性化の抑制効果"},{"subitem_title":"Inhibition of astrocytic activation in brain disorders and neuronal cell transplantation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"53157","relation_version_is_last":true,"title":["中枢神経障害および神経細胞移植におけるアストロサイト活性化の抑制効果"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:47.984003+00:00"}