@techreport{oai:kanazawa-u.repo.nii.ac.jp:00053173,
 month = {Jun},
 note = {37例の悪性骨軟部腫瘍患者に対し、樹状細胞療法を行なった。患者から得た単核球をG-CSFとIL-4により成熟させ、OK-432、液体窒素処理した腫瘍組織から得られたtumor lysateによって樹状細胞を刺激した。得られた樹状細胞を患者に皮下注射するという治療を6回くり返した。結果として、樹状細胞療法による重篤な副作用は見られなかった。また、OK-432、tumor lysateにより樹状細胞の成熟度は上昇した。効果として、6例でSD、1例でPRであり、3年生存率は42.3%、3年無増悪生存率は2.9%であった。, Thirty seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing IL-4 and GM-CSF. These cells were treated with tumor lysate, TNF-α, and OK-432. One treatment course comprised weekly DC injection for 6 times. Toxicity, clinical response (tumor volume, serum IFN-γ, and serum IL-12), and oncological outcomes were observed. DC therapy were performed in 37 patients. No severe adverse event and death associated with the DC injections were observed in the study patients. Increased serum IFN-γ and IL-12 were observed 1 month after DC injection. 6 cases had stable disease, and 1 case showed partial response 3 months after DC therapy. Of the 37 patients, 13 patients were alive and 1 patient was progression free at the time of the final follow-up. Overall survival rates and progression free survival rates of the patients at 3 years were 42.3% and 2.9%, respectively., 研究課題/領域番号:25293318, 研究期間(年度):2013-04-01 – 2016-03-31, 出典：研究課題「悪性骨腫瘍に対する液体窒素処理と樹状細胞療法の併用療法」課題番号25293318
（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） 
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25293318/25293318seika/）を加工して作成, 金沢大学医薬保健研究域医学系},
 title = {悪性骨腫瘍に対する液体窒素処理と樹状細胞療法の併用療法},
 year = {2016}
}