{"created":"2023-07-27T06:56:20.764475+00:00","id":53179,"links":{},"metadata":{"_buckets":{"deposit":"ad9dc105-9e50-4fb4-8bd6-d565c99bf80c"},"_deposit":{"created_by":18,"id":"53179","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53179"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053179","sets":["2812:2813:2818"]},"author_link":["2900"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HP1γは神経幹細胞の条件的ヘテロクロマチン領域においてヒストンH3K9me3やH3K9me2だけでなく，H3K27me3の維持に関わることが示唆された。また，Jmjd3欠損マウス，Jmjd3酵素活性特異的変異マウスおよびUtx欠損マウスを作製し，UtxではなくJmjd3がHox遺伝子の制御に関わること，Jmjd3はHox遺伝子の発現開始制御に関わること，Jmjd3は脱メチル化酵素活性を介してHox遺伝子の制御に関わることを明らかにした。さらに，胎盤におけるインプリンティング遺伝子の発現異常がポリコーム因子のリクルートができないことによる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"HP1gamma mutant neurospheres had tendency to differentiate into neurons and astrocytes, and not only H3K9 but H3K27 methylation decreased in HP1gamma mutant neurospheres. Jmjd3 and Utx are H3K27 demethylases and thought to be involved in the many human diseases, however, the functional differences between Jmjd3 and Utx in mammals are still unclear. We examined both Jmjd3 and Utx deficient embryos. The results suggest that Jmjd3, but not Utx is involved in the axial patterning through Hox regulation in mice in contrast to previous reports that not Jmjd3 but Utx determines the axis formation via Hox regulation in zebrafish and nematode. Furthermore, Jmjd3 mouse mutants lacking only demethylase activity were examined since Jmjd3 functions in two ways: demethylase-dependent and independent. They showed the same phenotypes as Jmjd3 deficient embryos, suggesting that demethylase activity of Jmjd3 is crucial for the axial patterning in mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25430085, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒストン修飾によるインプリンティング遺伝子制御の解析と周産期致死疾患モデルの開発」課題番号25430085\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25430085/25430085seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"京都大学 / 金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059464","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=30372486"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=30372486","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25430085/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25430085/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25430085/25430085seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25430085/25430085seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-23"}],"displaytype":"detail","filename":"FR-PR-NARUSE-C-kaken 2016-5p.pdf","filesize":[{"value":"83.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-NARUSE-C-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53179/files/FR-PR-NARUSE-C-kaken 2016-5p.pdf"},"version_id":"e0a1503d-eb16-4d36-8215-efb4b504f466"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒストン修飾によるインプリンティング遺伝子制御の解析と周産期致死疾患モデルの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒストン修飾によるインプリンティング遺伝子制御の解析と周産期致死疾患モデルの開発"},{"subitem_title":"The roles of histone modifications in the perinatal period.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"53179","relation_version_is_last":true,"title":["ヒストン修飾によるインプリンティング遺伝子制御の解析と周産期致死疾患モデルの開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:52:14.847293+00:00"}