{"created":"2023-07-27T06:56:21.214194+00:00","id":53190,"links":{},"metadata":{"_buckets":{"deposit":"f0843a11-7692-484d-a8c5-1a0383efb152"},"_deposit":{"created_by":18,"id":"53190","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53190"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053190","sets":["2812:2813:2818"]},"author_link":["2025","24454"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"①発生初期における酸化ストレス曝露は将来の脳脆弱性につながる。一方、成熟脳に対する酸化ストレスの影響については、これまで殆ど検討されていかった。我々は、薬理学的に一過性のマイルドな酸化ストレスを急性あるいは慢性にラットに負荷し、認知機能や意思決定に対する影響を検討した。その結果、慢性CHX負荷は、うつ病などの特定の精神疾患の表現系を模倣しなかったが、複数の行動指標に長期的な影響を与えることを確認した。\n②CHXをコカインと同日に慢性投与したところ、投与終了３週間後に常同行動のみ増強した。この増強には個体差がなかった。従ってCHX同日負荷はコカイン依存を促進する作用があると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"①Exposure of neonates to oxidative stress may increase the risk of psychiatric disorders such as schizophrenia in adulthood. However, the effects of moderate oxidative stress on the adult brain are not completely understood. To address this issue, we systemically administrated 2-cyclohexen-1-one (CHX) to adult rats to transiently reduce glutathione levels. As a result, we found that repeated administration of CHX to adult rats did not cause a specific mental disorder, but it induced long-term alterations in behavioral and cognitive functions, possibly related to specific neural correlates.\n②Repeated co-administration of CHX with cocaine to rats did not induce any additional effect while the administration. Howwever, after a 3-weeks of withdrawal period, the animals displayed enhanced stereotypie without exception, suggesting that additional CHX treatment on cocaine strongly augmented late-developing behavioral sensitization.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461727, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「酸化ストレスが精神疾患病態生理に果たす機能的重要性の解明: うつ病の敵か、味方か？」課題番号25461727\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25461727/25461727seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059475","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00323006"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00323006","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25461727/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25461727/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25461727/25461727seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25461727/25461727seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-05"}],"displaytype":"detail","filename":"HO-PR-TODA-S-kaken 2016-4p.pdf","filesize":[{"value":"430.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TODA-S-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53190/files/HO-PR-TODA-S-kaken 2016-4p.pdf"},"version_id":"7cc8f54e-ebca-407d-a971-e664f5ac0759"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"酸化ストレスが精神疾患病態生理に果たす機能的重要性の解明: うつ病の敵か、味方か？","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸化ストレスが精神疾患病態生理に果たす機能的重要性の解明: うつ病の敵か、味方か？"},{"subitem_title":"Elucidating the functional significance of mild oxidative stress on adult rat brain: friend or foe?","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"53190","relation_version_is_last":true,"title":["酸化ストレスが精神疾患病態生理に果たす機能的重要性の解明: うつ病の敵か、味方か？"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:51:48.727196+00:00"}