{"created":"2023-07-27T06:56:21.304101+00:00","id":53192,"links":{},"metadata":{"_buckets":{"deposit":"84a637b6-c764-4dde-86cc-f5563b997c07"},"_deposit":{"created_by":18,"id":"53192","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53192"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053192","sets":["2812:2813:2820"]},"author_link":["566"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011 – 2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ノスカピンは臨床的に使用可能な安全な薬であり、MDR発現癌にも抗腫瘍作用が認められている。腎癌の薬剤耐性にMDR高発現が関与すると考えられているため、腎癌細胞ACHNにノスカピンを加え、in vitro, in vivoにおいて抗腫瘍効果を確認した。前立腺癌細胞株においても抗腫瘍効果を確認し、MDR高発現しているパクリタキセル耐性前立腺癌細胞株DU145-TxRでも同様の抗腫瘍効果を観察した。さらに、前立腺癌においてノスカピンと植物フラボノイドによる相乗的効果を期待する目的で、植物フラボノイドのアンドロゲン応答性に対する抑制効果を調査し、ナリンゲニンが強い抑制作用のあることを観察した。","subitem_description_type":"Abstract"},{"subitem_description":"Noscapine is clinically available safe medicine, and antitumor action is found in MDR-overexpressing cancer. Because it was considered that MDR overexpression was involved in drug resistance of the renal carcinoma, we added Noscapine to renal carcinoma cells ACHN and confirmed antitumor effect in in vitro and in vivo. We confirmed antitumor effect in the prostate cancer cell line. Noscapine inhibited the proliferation of not only androgen-independent prostate caner cells DU145 but also DU145-TxR which is resistant for paclitaxel and docetaxel.DU145-TxR overexpressed MDR mRNA and p-glycoprotein that stimulate.\nFor the purpose of expecting a synergistic effect with noscapine and flavonoids in prostate cancer, we investigated the effect of flavonoids on the androgen responsiveness. After LNCaP cells were transfected with PSA promoter-driven Luciferase reporter, cells were treated with DHT with flavonoids. Then naringenin showed the strong suppression of androgen responsiveness.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23592327, 研究期間(年度):2011 – 2013","subitem_description_type":"Other"},{"subitem_description":"出典：「ノスカピン誘導体EM101の腎細胞癌に対する抗腫瘍効果及びそのメカニズムの検討」研究成果報告書　課題番号23592327\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23592327/23592327seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059477","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60467107"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60467107","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23592327/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23592327/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23592327/23592327seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23592327/23592327seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"ME-PR-MIYAGI-T-kaken 2014-4p.pdf","filesize":[{"value":"325.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIYAGI-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53192/files/ME-PR-MIYAGI-T-kaken 2014-4p.pdf"},"version_id":"8917ce9e-ed37-407c-be7c-28b22022303a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ノスカピン誘導体EM101の腎細胞癌に対する抗腫瘍効果及びそのメカニズムの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ノスカピン誘導体EM101の腎細胞癌に対する抗腫瘍効果及びそのメカニズムの検討"},{"subitem_title":"Effect of Noscapine and its derivative, EM101, on renal cell cancer and their mechanisms","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"53192","relation_version_is_last":true,"title":["ノスカピン誘導体EM101の腎細胞癌に対する抗腫瘍効果及びそのメカニズムの検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:33.852316+00:00"}