{"created":"2023-07-27T06:56:23.011427+00:00","id":53227,"links":{},"metadata":{"_buckets":{"deposit":"fbb35e35-72eb-4210-aaa7-91f0d19924bc"},"_deposit":{"created_by":18,"id":"53227","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53227"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053227","sets":["2812:2813:2822"]},"author_link":["94639","69608"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010 – 2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は中枢神経再生が可能である魚類より得た新規細胞外マトリックス因子プルプリンをアデノ随伴ウイルスベクターを使ってほ乳類に応用し、損傷後視神経を再生させることを目的とした。プルプリンは接着斑キナーゼを活性化させ、細胞接着作用と細胞生存作用を示した。そのメカニズムはマトリックスメタロプロテアーゼ9の活性阻害によりラミニンを安定させることにあった。プルプリンおよびそのメカニズムが将来的に緑内障治療に貢献できることを期待する。","subitem_description_type":"Abstract"},{"subitem_description":"In our strategies toward optic nerve regeneration of mammals using fish derived molecule, we used purpurin(a novel extracellular matrix protein) overexpression systems by adeno-associated virus vector in rat retina. In rat, supply of purpurin could protect retinal ganglion cells(RGCs) from injury-induced apoptosis through a mechanism of focal adhesion kinase(FAK)/Akt activation. Furthermore, purpurin had adhesive effect on rat RGCs from culture study with purpurin-coated dishes. We focused on the extracellular matrix-related molecules as a mechanism of purpurin adhesive and survival effects. Purpurin inhibited optic injury-induced matrix metalloprotease 9 activity and the degradation of laminin and activated FAK signaling. Purpurin could potentially offer new avenues for developing treatments for human retinal degenerative disorders such as glaucoma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22791651, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新規細胞外マトリックスタンパク質による神経再生の分子基盤解明と緑内障治療への応用」課題番号22791651\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22791651/22791651seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059511","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70397199"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70397199","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22791651/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22791651/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22791651/22791651seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22791651/22791651seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-05"}],"displaytype":"detail","filename":"ME-PR-KORIYAMA-Y-kaken 2012-4p.pdf","filesize":[{"value":"249.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KORIYAMA-Y-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53227/files/ME-PR-KORIYAMA-Y-kaken 2012-4p.pdf"},"version_id":"a0a41758-32fd-41d4-8c90-2409ce296de0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規細胞外マトリックスタンパク質による神経再生の分子基盤解明と緑内障治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規細胞外マトリックスタンパク質による神経再生の分子基盤解明と緑内障治療への応用"},{"subitem_title":"The role of novel extracellular matrix protein on CNS regeneration and its application study for glaucoma treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"53227","relation_version_is_last":true,"title":["新規細胞外マトリックスタンパク質による神経再生の分子基盤解明と緑内障治療への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:25.337095+00:00"}