{"created":"2023-07-27T06:56:23.413562+00:00","id":53233,"links":{},"metadata":{"_buckets":{"deposit":"34407166-f33d-44b8-a87a-d38b13b0db82"},"_deposit":{"created_by":18,"id":"53233","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53233"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053233","sets":["2812:2813:2821"]},"author_link":["70071","94645"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010 – 2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病(AD)ではアミロイドβ蛋白(Aβ)のオリゴマーが注目されている。Photo-induced cross-linking of unmodified proteins法を用いて、33例のAD患者と対照として33例の非認知症性疾患患者の脳脊髄液のAβのオリゴマー化に対する効果を検討した。脳脊髄液はAβ40およびAβ42のオリゴマー化を抑制した。更に、脳脊髄液のAβオリゴマー化の抑制効果は、AD患者の脳脊髄液が対照群よりも有意に弱かった。AD患者はAβのオリゴマー化を促進する脳脊髄液環境を有しているものと推察された。","subitem_description_type":"Abstract"},{"subitem_description":"Oligomers of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease (AD). We investigated the effect of cerebrospinal fluid (CSF) from 33 patients with AD and 33 age-matched, non-demented controls on oligomerization of Aβ40 and Aβ42 usingphoto-induced cross-linking of unmodified proteins. CSF inhibited oligomerization of both Aβ40 and Aβ42. This inhibitory effect was significantly weaker in AD patients than in non-demented controls. Our results indicate that AD patients have a CSF environment favorable for Aβ oligomerization.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22790815, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒト生体試料のアミロイドβ蛋白オリゴマー形成への影響の解析」課題番号22790815\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22790815/22790815seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059517","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70377381"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70377381","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22790815/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22790815/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22790815/22790815seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22790815/22790815seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-05"}],"displaytype":"detail","filename":"HO-PR-ONO-K-kaken 2013-5p.pdf","filesize":[{"value":"322.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-ONO-K-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53233/files/HO-PR-ONO-K-kaken 2013-5p.pdf"},"version_id":"bdded866-33e3-4aa7-87eb-79b872b778c9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト生体試料のアミロイドβ蛋白オリゴマー形成への影響の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト生体試料のアミロイドβ蛋白オリゴマー形成への影響の解析"},{"subitem_title":"Analysis of the effect of human living specimen on amyloid β-protein oligomerization","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"53233","relation_version_is_last":true,"title":["ヒト生体試料のアミロイドβ蛋白オリゴマー形成への影響の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:00:03.619856+00:00"}