{"created":"2023-07-27T06:56:24.357622+00:00","id":53247,"links":{},"metadata":{"_buckets":{"deposit":"af52cd67-d776-4eb4-af6d-8e9b843f53aa"},"_deposit":{"created_by":18,"id":"53247","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53247"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053247","sets":["2812:2813:2826"]},"author_link":["422"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"2006 – 2007","bibliographic_titles":[{"bibliographic_title":"平成19(2007)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2007 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】大動脈瘤に対するステントグラフト内挿術において大動脈壁と人工血管膜との間の生物学的固着を積極的に促進させ治療効果を能動的に高めることを目標とし、本研究では線維芽細胞増殖因子(以下、bFGF)溶出型のステントグラフトを開発、生体内で生じる組織変化を評価検討し、薬剤溶出型ステントグラフトの臨床応用の可能性を模索することを目的とした。\n【対象と方法】薬剤キャリアとしてハイドロゲルを用いた。ステントグラフトは頭側より1.A群(非ハイドロゲルコーティンググラフト+蒸留水)、2.B群(ハイドロゲルコーティンググラフト+蒸留水)、3.C群(ハイドロゲルコーティンググラフト+bFGF)とし、6頭の生体ブタの腹部大動脈にそれぞれ留置した。30日後の血管造影、血管内超音波及び組織標本(HE染色、EVG染色、α平滑筋アクチンによる免疫染色)にて宿主血管壁との間に生じる組織変化を比較した。\n【結果】新生内膜比(%、血管断面積における新生内膜の占める面積比)は、A群9.26±1.39(SEM)、B群12.6±1.71、C群21.3±3.04であり、A-C群、B-C群において有意差を示した(P<0.05)。C群ではグラフトの織り込まれた繊維内にα平滑筋アクチン陽性細胞を多数認め、この細胞数はA,B群と比し有意に多かった。\n【結論】bFGFの徐放により新生内膜形成及びグラフト繊維内へのα平滑筋アクチン陽性細胞の侵入が促進されることが示唆され、宿主動脈壁と人工血管膜との間に強固な固着が生じることが期待できると思われた。現在は、ステントグラフト自体の大動脈壁に対する適合性を高める研究を進めており、今後適合性に優れたステントグラフトに本研究の結果を応用し、より積極的な大動脈ステントグラフト治療の臨床応用が実現化できれば、大動脈疾患に対する低侵襲治療として遠隔成績が期待され、外科手術治療に対する高危険群患者にとって朗報になりうると考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"PURPOSE: To evaluate the local reaction of the aortic wall induced by basic fibroblast growth factor (bFGF) released from a gelatin hydrogel coated on the outer surface of a stent-graft for the purpose of biological fixation.\nMETHODS: A total of 18 nitinol-based, polyester-covered stent-grafts were implanted in 6 porcine aortas for 1 month. The implanted stent-grafts were divided into 3 groups: the control group (uncoated), the hydrogel group (coated with hydrogel containing water), and the bFGF group (coated with hydrogel containing bFGF). After stent-graft implantation, the results of intravascular ultrasound (IVUS) and qualitative and quantitative microscopic examinations were compared among the groups.\nRESULTS: In the bFGF group, a thin white lamellar tissue was observed on IVUS images. Significantly more new intimal tissue formation was observed in all the bFGF group animals than in the other 2 groups, and alpha smooth muscle (SM) actin-positive cells (alphaSMCs) were detected in this new tissue. The alphaSMCs within the fabric of tightly woven grafts were significantly more abundant in the bFGF group than in the other groups.\nCONCLUSION: The local controlled release of bFGF from the stent-graft significantly accelerated the proliferation of new intimal tissue between the aorta and the stent-graft and within the graft materials. These findings suggest that a graft can be fixed biologically to the aortic wall, which may contribute to the shrinkage of aneurysms following stent-grafting.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18591333, 研究期間(年度):2006 – 2007","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「線維芽細胞増殖因子溶出型ハイドロゲル化ステントグラフト開発に関する実験的研究」課題番号18591333\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18591333/185913332007kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059531","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10313652"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10313652","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18591333/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18591333/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18591333/185913332007kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18591333/185913332007kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-16"}],"displaytype":"detail","filename":"HO-PR-SANADA-J-kaken 2010-3p.pdf","filesize":[{"value":"121.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SANADA-J-kaken 2010-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53247/files/HO-PR-SANADA-J-kaken 2010-3p.pdf"},"version_id":"ec20a9da-46d8-4bd9-a930-66536a89eca2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"線維芽細胞増殖因子溶出型ハイドロゲル化ステントグラフト開発に関する実験的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"線維芽細胞増殖因子溶出型ハイドロゲル化ステントグラフト開発に関する実験的研究"},{"subitem_title":"Hydrogel-mediated release of basic fibroblast growth factor from a stent-graft accelerates biological fixation with the aortic wall in a porcine mode","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2826"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-16"},"publish_date":"2022-05-16","publish_status":"0","recid":"53247","relation_version_is_last":true,"title":["線維芽細胞増殖因子溶出型ハイドロゲル化ステントグラフト開発に関する実験的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:06:30.059739+00:00"}