{"created":"2023-07-27T06:56:24.760874+00:00","id":53254,"links":{},"metadata":{"_buckets":{"deposit":"52d16d30-7942-4169-9053-b68ca612b1c4"},"_deposit":{"created_by":18,"id":"53254","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53254"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053254","sets":["2812:2813:2819"]},"author_link":["83484","361"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞の不死化に関連する酵素の一つであるテロメラーゼの活性サブユニットであるhuman telomerase reverse transcriptase (hTERT)のプロモーターをadenovirusに組み込むことで，癌特異的な発現ベクターを構築した．細胞数を調整した腎癌細胞株ACHN，前立腺癌細胞株PC3，LNCaP，DU145を健康成人血液中に混注したサンプルにて血液中の癌細胞を同定することが可能であったが，検出には血液1ml中に100-1000個の癌細胞が必要であり，精度は低かった．泌尿器癌患者30例の血液サンプルでは血液中の癌細胞を同定できず，結果を得るのに至らなかった．","subitem_description_type":"Abstract"},{"subitem_description":"Novel adenovirus vector with human telomerase reverse transcriptase (hTERT) promoter could be constructed. In vitro, renal cancer cells (ACHN) and prostate cancer cells (PC3, LNCaP, DU145) were detected in human blood using this vector, however, 100 to 1000 cells were needed to detect in 1 ml of human blood, which was insufficient for the clinical practice. In vivo, circulating tumor cells could not be detected in the human blood samples of 30 patients with urological cancers (10 renal cell carcinoma, 12 urothelial carcinoma, 8 prostate cancer).","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24592381, 研究期間(年度):2012-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「テロメア動態と上皮間葉移行機序を応用した血管内浮遊癌細胞に対する治療戦略」課題番号24592381\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24592381/24592381seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059538","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00452102"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00452102","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24592381/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24592381/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24592381/24592381seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24592381/24592381seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"HO-PR-KITAGAWA-Y-kaken 2015-4p.pdf","filesize":[{"value":"154.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KITAGAWA-Y-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53254/files/HO-PR-KITAGAWA-Y-kaken 2015-4p.pdf"},"version_id":"757226e3-97c1-47b9-8dd6-3504ab3c6a34"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"テロメア動態と上皮間葉移行機序を応用した血管内浮遊癌細胞に対する治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"テロメア動態と上皮間葉移行機序を応用した血管内浮遊癌細胞に対する治療戦略"},{"subitem_title":"Treatment strategy for circulating tumor cell using telomerase activity with epithelial-mesenchymal transition","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"53254","relation_version_is_last":true,"title":["テロメア動態と上皮間葉移行機序を応用した血管内浮遊癌細胞に対する治療戦略"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:41:11.868783+00:00"}