{"created":"2023-07-27T06:56:24.894902+00:00","id":53256,"links":{},"metadata":{"_buckets":{"deposit":"b9be360e-1fb0-47b3-9129-37e88aff45b3"},"_deposit":{"created_by":18,"id":"53256","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53256"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053256","sets":["2812:2813:2819"]},"author_link":["304"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IFN-γ、IL-4、IL-17Aの各欠損マウスに、ブレオマイシン連日皮内投与による強皮症モデルを誘導した。 このうち、IL-17A欠損マウスだけが有意に皮膚硬化が軽減した。IL-17Aの欠損により、白血球の皮膚浸潤やTGF-β や CTGFの発現が抑制された。ブレオマイシンの注射は、Th17細胞の分化を誘導し、皮膚におけるIL-17A発現を増強させた。皮膚の培養線維芽細胞は、IL-17Aの添加によりTGF-β、CTGF、コラーゲンの産生を増加させた。IL-17Aが、TGF-βやCTGFの発現を促進することにより、強皮症の線維化に関与している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To compare the roles of Th1, Th2, and Th17 cytokines, we applied bleomycin-induced scleroderma model to mice deficient for interferon (IFN)-γ, interleukin (IL) -4, and IL-17A. The loss of IL-17A significantly attenuated bleomycin-induced skin fibrosis, whereas deficiency of IFN-γ or IL-4 did not. The leukocyte infiltration and mRNA expression levels of TGF-β and CTGF in the bleomycin-injected skin were significantly reduced in IL-17A-deficient mice. Bleomycin injection stimulated the differentiation of naive T cells into Th17 cells and increased IL-17 expression in the skin. Cell lines of skin fibroblasts expressed increased TGF-β, CTGF, and collagen by the addition of IL-17A. IL-17A, a representative Th17 cytokine, plays a dominant role during the development of skin fibrosis. That is, bleomycin injection induces IL-17A production and increased IL-17A likely stimulates collagen production from fibroblasts probably via cytokine production such as TGF-β and CTGF in mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24591644, 研究期間(年度):2012-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「サイトカインを標的とする強皮症の治療戦略」課題番号24591644\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24591644/24591644seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"福井大学 / 金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059540","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50283130"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50283130","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24591644/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24591644/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24591644/24591644seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24591644/24591644seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"HO-PR-HASEGAWA-M-kaken 2015-5p.pdf","filesize":[{"value":"226.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-HASEGAWA-M-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53256/files/HO-PR-HASEGAWA-M-kaken 2015-5p.pdf"},"version_id":"50cd9b3e-ff01-494f-91cf-d68f7c88b02c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サイトカインを標的とする強皮症の治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サイトカインを標的とする強皮症の治療戦略"},{"subitem_title":"Cytokine-targeted therapy of scleroderma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"53256","relation_version_is_last":true,"title":["サイトカインを標的とする強皮症の治療戦略"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:41:06.512560+00:00"}