{"created":"2023-07-27T06:56:28.377501+00:00","id":53308,"links":{},"metadata":{"_buckets":{"deposit":"7aa62489-67d3-47fd-a151-d8988ab8a4f9"},"_deposit":{"created_by":18,"id":"53308","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53308"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053308","sets":["2812:2813:2822"]},"author_link":["94694"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010 – 2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々が作製したHP1γ変異マウスを解析した結果、減数分裂の進行時にHP1γはセントロメア近傍におけるヒストン修飾因子のリクルートに必須であることが明らかになった。また、減数分裂以前の始原生殖細胞(PGC)の増殖にもHP1γが必須であることを明らかにした。さらに、ヒストン脱メチル化酵素の変異マウスは骨格の発生に異常を起こして出生直後致死となること、骨格の発生異常はHox遺伝子の発現制御の異常によることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"We generated HP1 gamma mutant mice and found that histone methylation at pericentromeric heterochromatin was reduced in the mutant germ cells at meiosis. Next, we found that HP1 gamma is essential for cell cycle progression of primordial germ cells(PGC). Moreover, we found that histone demethylase regulates expression of Hox genes, and the demethylase-deficient mice died perinatally.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22700451, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒストン修飾因子変異マウスが不妊症を呈するメカニズムの解析」課題番号22700451\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22700451/22700451seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059592","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=30372486"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=30372486","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22700451/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22700451/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22700451/22700451seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22700451/22700451seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-05"}],"displaytype":"detail","filename":"FR-PR-NARUSE-C-kaken 2012-4p.pdf","filesize":[{"value":"212.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-NARUSE-C-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53308/files/FR-PR-NARUSE-C-kaken 2012-4p.pdf"},"version_id":"ee1de351-057f-4360-82db-167245fd18bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒストン修飾因子変異マウスが不妊症を呈するメカニズムの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒストン修飾因子変異マウスが不妊症を呈するメカニズムの解析"},{"subitem_title":"Analyses of mutant mice lacking histone modification factors.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"53308","relation_version_is_last":true,"title":["ヒストン修飾因子変異マウスが不妊症を呈するメカニズムの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:18.510080+00:00"}