{"created":"2023-07-27T06:56:29.786970+00:00","id":53329,"links":{},"metadata":{"_buckets":{"deposit":"f21fa139-3100-44b9-ac06-38cd249aff44"},"_deposit":{"created_by":18,"id":"53329","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53329"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053329","sets":["2812:2813:2822"]},"author_link":["234"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009 – 2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"免疫関連遺伝子多型を臨床的に検討し、NKG2D、Granzyme B、HO-1、CXCL10、NLRP3、FCGR3A、IL-17、PTPN22各遺伝子多型が、非血縁者間骨髄移植後転帰に影響することを明らかにした。さらに、実験的検討により、NKG2D、IL-17、CXCL10が機能的多型であることを示した。このような情報は、同種造血幹細胞移植成績向上に大きく役立つと期待される。","subitem_description_type":"Abstract"},{"subitem_description":"When the impact of immune-related gene polymorphisms was examined in patients and their donors of unrelated hematopoietic stem cell transplantation, genetic variations in the NKG2D, Granzyme B, CXCL10, NLRP3, FCGR3A, IL-17, and PTPN22 genes were associated with transplant outcomes. Experimental investigation revealed that the gene polymorphisms of NKG2D, IL-17 and CXCL10 play functionally important roles in the regulation of their production. These findings suggest that determination of such gene polymorphisms prior to transplantation offer clinical benefits in patients undergoing allogeneic hematopoietic stem cell transplantation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21591236, 研究期間(年度):2009 – 2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「免疫関連遺伝子多型解析に基づく最適な造血幹細胞移植ドナー選択法の確立」課題番号21591236\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21591236/21591236seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059613","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80324078"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80324078","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21591236/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21591236/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21591236/21591236seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21591236/21591236seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-23"}],"displaytype":"detail","filename":"HO-PR-TAKAMI-A-kaken 2012-6p.pdf","filesize":[{"value":"230.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKAMI-A-kaken 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53329/files/HO-PR-TAKAMI-A-kaken 2012-6p.pdf"},"version_id":"e349cd10-c872-4cfb-81e8-21f3ac8aa63f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"免疫関連遺伝子多型解析に基づく最適な造血幹細胞移植ドナー選択法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫関連遺伝子多型解析に基づく最適な造血幹細胞移植ドナー選択法の確立"},{"subitem_title":"Establishment of optimal hematopoietic stem cell transplantation donor selection based on analysis of immune-related gene polymorphism","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"53329","relation_version_is_last":true,"title":["免疫関連遺伝子多型解析に基づく最適な造血幹細胞移植ドナー選択法の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:40.873361+00:00"}