{"created":"2023-07-27T06:56:30.327154+00:00","id":53337,"links":{},"metadata":{"_buckets":{"deposit":"253f30c7-ef4a-45c6-b15a-abdbaaea67bf"},"_deposit":{"created_by":18,"id":"53337","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53337"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053337","sets":["2812:2813:2821"]},"author_link":["33"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010 – 2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高次脳機能における糖鎖の役割を明らかにするために様々な糖鎖遺伝子の改変マウスを用いて,行動実験を中心に解析を行なった。β4GalT-2欠損マウスやC6ST-1 Tgマウスでは新奇刺激に対する過敏性や注意機能の異常が認められ,ドーパミン系の異常が示唆された。脳特異的β4GalT-5とβ4GalT-6欠損マウスでは活動性の変化や注意機能の異常が見られ,ミエリン形成の異常が示唆された。このように糖鎖は高次脳機能に重要な役割を持っていることが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"To elucidate the role of carbohydrates in higher brain functions, we investigated glycogene-manipulated mice using behavioral analysis. β4GalT-2 KO mice and C6ST-1 Tg mice showed hypersensitive to novel stimuli and disturbed attention, and were suggested to be impaired in the dopamine system. β4GalT-5 KO mice and β4GalT-6 KO mice showed abnormal activity and disturbed attention, and were suggested to be impaired in myelin formation. These results indicated that carbohydrates play an important role in higher brain functions.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22300142, 研究期間(年度):2010 – 2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「高次脳機能におけるガラクトースやシアル酸糖鎖の機能解析」課題番号22300142\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22300142/22300142seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059621","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50251450"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50251450","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22300142/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22300142/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22300142/22300142seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22300142/22300142seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"FR-PR-ASANO-M-kaken 2013-5p.pdf","filesize":[{"value":"346.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-ASANO-M-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53337/files/FR-PR-ASANO-M-kaken 2013-5p.pdf"},"version_id":"1efad5ee-e4de-4d71-be45-13cd66a427c4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高次脳機能におけるガラクトースやシアル酸糖鎖の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高次脳機能におけるガラクトースやシアル酸糖鎖の機能解析"},{"subitem_title":"The role of carbohydrates including galactose and sialic acids in higher brain functions","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"53337","relation_version_is_last":true,"title":["高次脳機能におけるガラクトースやシアル酸糖鎖の機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:01:21.579084+00:00"}