{"created":"2023-07-27T06:56:30.797705+00:00","id":53344,"links":{},"metadata":{"_buckets":{"deposit":"83f03a29-4d14-48ec-9706-ee39912b4b40"},"_deposit":{"created_by":18,"id":"53344","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53344"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053344","sets":["2812:2813:2819"]},"author_link":["477"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-04-28 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝性リパーゼ(HL)が非アルコール性脂肪肝炎(NASH)の診断に有力なマーカーとなるか検討した。対象はアルゼンチン人の非アルコール性脂肪性肝炎(NASH)を疑われた42名。\nSteatosis gradeを3段階に分類し各群のHL活性を測定。HL活性は各群で差がなし。一方、肝生検された日本人31名でも検討した結果、HL活性はNASH(-)群、NASH(+)群でそれぞれ差がなし。HL活性で評価することの限界性が示唆され、抗ヒトモノクローナル抗体を用いたHL蛋白量のELISA系を確立した。HL蛋白量はHL活性より肝酵素ALTとの相関性に優れ、NASH検出に優れる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated whether hepatic lipase in post-heparin plasma could be a useful marker for diagnosing non-alcoholic steato hepatitis (NASH).Forty-two Argentines and thirty-one Japanese patients were involved in this study.\nIn Argentines, steatosis grade were classified into 3 grades and there were no significant differences in HL activities among the three groups. In Japanese patients, there was no difference in HL activities between subjects with and without NASH. These findings suggest that there is a limitation of applying HL activity as a method of reflecting HL. Alternatively we established a new enzyme-linked immunosorbent assay system for human HL protein mass. The correlation coefficients between alanine aminotransferase (ALT) and HL activity was 0.185(p<0.05) whereas those between ALT and HL mass was (0.285 p<0.01). This suggest that HL mass is superior to HL activity for detecting NASH.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590663, 研究期間(年度):2011-04-28 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「非アルコール性脂肪肝炎の予測因子としての脂質代謝酵素測定意義の樹立」課題番号23590663\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23590663/23590663seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢医科大学 / 金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059628","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60302577"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60302577","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23590663/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23590663/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23590663/23590663seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23590663/23590663seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"ME-PR-KOBAYASHI-J-kaken 2015-5p.pdf","filesize":[{"value":"191.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOBAYASHI-J-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53344/files/ME-PR-KOBAYASHI-J-kaken 2015-5p.pdf"},"version_id":"a881ffee-f181-4331-8855-b4a28d0bc11f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"非アルコール性脂肪肝炎の予測因子としての脂質代謝酵素測定意義の樹立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"非アルコール性脂肪肝炎の予測因子としての脂質代謝酵素測定意義の樹立"},{"subitem_title":"Clinical significance of measuring lipolytic enzyme for predicting non-alcoholic steato hepatitis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-05"},"publish_date":"2020-11-05","publish_status":"0","recid":"53344","relation_version_is_last":true,"title":["非アルコール性脂肪肝炎の予測因子としての脂質代謝酵素測定意義の樹立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:41:20.565457+00:00"}