{"created":"2023-07-27T06:56:30.932155+00:00","id":53346,"links":{},"metadata":{"_buckets":{"deposit":"2f9a54e9-ddbf-451c-a5f6-e2772487493b"},"_deposit":{"created_by":18,"id":"53346","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53346"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053346","sets":["2812:2813:2820"]},"author_link":["342"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011 – 2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高比重リポ蛋白(HDL)コレステロールよりもHDLの組成変化が冠動脈疾患発症に係わる可能性がある．本研究はHDL組成異常としてHDLトリグリセライド(TG)/HDLリン脂質(PL)比の上昇が種々の動脈硬化リスクと有意の相関が見られることを明らかにした． 同比率は特に糖尿病や慢性腎疾患との相関が強くHDL機能低下と関連する可能性がある．本邦ではコレステリルエステル転送蛋白(CETP)欠損症が高頻度であるが，血中CETP蛋白量はHDL-TG/PLと正相関を示し，CETP欠損症ではHDL-TG/PL比は有意に低値であった．","subitem_description_type":"Abstract"},{"subitem_description":"Many studies suggest that high-density lipoprotein (HDL) composition may contribute to coronary atherosclerosis development rather than HDL-cholesterol. In this study, we demonstrated that increased HDL-TG/HDL-PL ratio was significantly associated with many cardiovascular risk factors. This index was strongly correlated with diabetes and chronic kidney disease, and may represent functional abnormalities of HDL.\nPlasma cholesteryl-ester transfer protein (CETP) mass showed positive correlation with HDL-TG/HDL-PL ratio. HDL-TG/HDL-PL ratio was significantly lower in CETP deficiency, common genetic background in Japan.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591334, 研究期間(年度):2011 – 2013","subitem_description_type":"Other"},{"subitem_description":"出典：「高比重リポ蛋白組成異常による冠動脈疾患進展の機序解明と制御」研究成果報告書　課題番号23591334\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23591334/23591334seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059630","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50313648"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50313648","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23591334/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23591334/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23591334/23591334seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23591334/23591334seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-02"}],"displaytype":"detail","filename":"ME-PR-NOHARA-A-kaken 2014-5p.pdf","filesize":[{"value":"173.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NOHARA-A-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53346/files/ME-PR-NOHARA-A-kaken 2014-5p.pdf"},"version_id":"9b25d9b7-35c5-4d63-b730-b063557d5039"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高比重リポ蛋白組成異常による冠動脈疾患進展の機序解明と制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高比重リポ蛋白組成異常による冠動脈疾患進展の機序解明と制御"},{"subitem_title":"High-density lipoprotein composition and development of coronary artery disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-02"},"publish_date":"2020-11-02","publish_status":"0","recid":"53346","relation_version_is_last":true,"title":["高比重リポ蛋白組成異常による冠動脈疾患進展の機序解明と制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:44.921303+00:00"}