{"created":"2023-07-27T06:56:31.065631+00:00","id":53349,"links":{},"metadata":{"_buckets":{"deposit":"b119f5c9-8e10-4510-9ab3-077cf966318d"},"_deposit":{"created_by":18,"id":"53349","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53349"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053349","sets":["2812:2813:2820"]},"author_link":["52586","95207"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011 – 2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では遺伝子スクリーニングのツールとして多用されるショウジョウバエ研究から始め、マウスでのin vivo／in vitroでの分子研究から、発達障害、精神疾患関連遺伝子の同定、機能研究を行うことを目指した。\n本研究期間中に、Robo2、Ect2、Fam107B（Hitと命名）の３遺伝子に絞り込み、このうち、Robo2に関してはヒト死後脳を使った自閉症臨床研究まで発展させることが出来た。また、新規遺伝子、Hitに関してはストレスホルモン応答性の遺伝子であり、同様の機能を持つSgk1（うつ病の危険因子と考えられている）と機能的関連性を持つことを突き止めた。","subitem_description_type":"Abstract"},{"subitem_description":"Starting from Drosophila genetic screening based on aggressive behavior, we aim to identify and study genes involved in human developmental disorders and psychiatric disorders such as depression. In this 3 years project, we finally reach 3 candidates, Robo2, Ect2 and Fam107B (we call it as \"Hit\") that is related to autism, mental retardation and depression.\nOne of them, Robo2 shows decreased expression in autistic human postmortem brain. Another gene, Hit responsible to stress hormone and related to function of Sgk1, a risk factor gene that may cause depression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23500427, 研究期間(年度):2011 – 2013","subitem_description_type":"Other"},{"subitem_description":"出典：「攻撃行動を指標とした自閉症、発達障害原因遺伝子の機能解析」研究成果報告書　課題番号23500427\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23500427/23500427seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学子どものこころの発達研究センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059632","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70377406"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70377406","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23500427/q"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23500427/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23500427/23500427seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23500427/23500427seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-02"}],"displaytype":"detail","filename":"CH-PR-KOIZUMI-K-kaken 2014-5p.pdf","filesize":[{"value":"379.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-KOIZUMI-K-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53349/files/CH-PR-KOIZUMI-K-kaken 2014-5p.pdf"},"version_id":"d62960b7-be16-4316-8926-ff86e2248455"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"攻撃行動を指標とした自閉症、発達障害原因遺伝子の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"攻撃行動を指標とした自閉症、発達障害原因遺伝子の機能解析"},{"subitem_title":"Functional screening and study of genes based on aggressive behavior, which is involved in autism and human developmental disorders.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-02"},"publish_date":"2020-11-02","publish_status":"0","recid":"53349","relation_version_is_last":true,"title":["攻撃行動を指標とした自閉症、発達障害原因遺伝子の機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:43.398136+00:00"}