{"created":"2023-07-27T06:56:31.603263+00:00","id":53357,"links":{},"metadata":{"_buckets":{"deposit":"dca469f4-b3bb-496e-936d-f33d4eb711e4"},"_deposit":{"created_by":18,"id":"53357","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53357"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053357","sets":["2812:2813:2823"]},"author_link":["95207"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008 – 2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、ヒト自閉症・発達障害に関わる遺伝子の同定を最終的な目的とし、ショウジョウバエ、マウスモデルを利用した二段階の遺伝子スクリーニング/機能解析を行った。すなわち約8800のショウジョウバエ遺伝子のスクリーニングからスタートし、マウスでの二次スクリーニング/機能解析から7つの遺伝子に絞り込み解析を進めた。このうちRoboIII/IV遺伝子については、ヒト自閉症者サンプルを用いた臨床研究から、自閉症との関連性を明らかにすることに成功した。","subitem_description_type":"Abstract"},{"subitem_description":"The final goal of this study is to identify new genes that are associated with autism/developmental disorders. For this purpose, we screened around 8800 genes in Drosophila as the first step and the second step studies in mice picked up 7 candidate genes, possibly, related to human developmental disorders. Our clinical study finally succeeded to figure out ones of these genes, RoboIII/IV are associated with autism.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20500323, 研究期間(年度):2008 – 2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「RNAiを利用したfly/mouse二段階スクリーニングによる自閉症遺伝子の探索」課題番号20500323\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20500323/20500323seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059640","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70377406"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70377406","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20500323/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20500323/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20500323/20500323seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20500323/20500323seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-02"}],"displaytype":"detail","filename":"CH-PR-KOIZUMI-K-kaken 2011-4p.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-KOIZUMI-K-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53357/files/CH-PR-KOIZUMI-K-kaken 2011-4p.pdf"},"version_id":"ca302e15-ea9d-46e6-88ca-bda4873d321c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"RNAiを利用したfly/mouse二段階スクリーニングによる自閉症遺伝子の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNAiを利用したfly/mouse二段階スクリーニングによる自閉症遺伝子の探索"},{"subitem_title":"Two steps screening of autistic genes by using Fly/mouse as model animals","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-02"},"publish_date":"2020-11-02","publish_status":"0","recid":"53357","relation_version_is_last":true,"title":["RNAiを利用したfly/mouse二段階スクリーニングによる自閉症遺伝子の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:23:01.096975+00:00"}