{"created":"2023-07-27T06:56:33.570251+00:00","id":53406,"links":{},"metadata":{"_buckets":{"deposit":"ca82cfd8-b604-4a23-8e5d-365427615215"},"_deposit":{"created_by":18,"id":"53406","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53406"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053406","sets":["2812:2813:2820"]},"author_link":["94738"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-08-31 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahata, Yoshifumi"}],"nameIdentifiers":[{"nameIdentifier":"94738","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60635845","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60635845"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"時計遺伝子Periodの転写制御に関する新たなフィードバック機構について探索を行った。その結果、Period2と相互作用する新規転写因子を発見し、この新規転写因子はE-boxを介したBmal1/Clockによる転写活性化を抑制することを明らかにした。さらに、この新規転写因子はPeriod2タンパク質の核内移行を促進させることや、Casein kinase Iにより導かれる分解を抑制する事を明らかにした。これらの結果から、今回同定した新規転写因子はPer2との結合を介して新たな転写制御機構に関与する事が推察される。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated a novel function of transcriptional feedback loop relevant to a mammalian clock gene, Period. Here, we report that a new transcription factor was identified as physically binding with Per2, and the transcription factor inhibited E-box regulated transcriptional activity by Bmal1/Clock. Further, we found that the transcription factor accelerated nuclear translocation of Per2, in addition inhibited Per2 degradation induced by casein kinase I. Accordingly, the transcription factor could play a role as a novel function of transcriptional regulation through the direct interaction with Per2.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24810009, 研究期間(年度):2012-08-31 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「時計遺伝子Periodの転写制御に関する新たなフィードバック機構の解析」研究成果報告書　課題番号24810009\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24810009/24810009seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域自然システム学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059689","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60635845"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60635845","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24810009"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24810009","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24810009/24810009seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24810009/24810009seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高畑, 佳史"}],"nameIdentifiers":[{"nameIdentifier":"94738","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60635845","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60635845"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"SC-PR-TAKAHASHI-Y-kaken 2014-4p.pdf","filesize":[{"value":"236.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC-PR-TAKAHASHI-Y-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53406/files/SC-PR-TAKAHASHI-Y-kaken 2014-4p.pdf"},"version_id":"f20c0a0f-665a-45c4-b27c-cd6f7f8fd8d9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"時計遺伝子Periodの転写制御に関する新たなフィードバック機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"時計遺伝子Periodの転写制御に関する新たなフィードバック機構の解析"},{"subitem_title":"Functional analysis of a transcriptional feedback loop related to a mammalian clock gene, Period","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"53406","relation_version_is_last":true,"title":["時計遺伝子Periodの転写制御に関する新たなフィードバック機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:51:58.575965+00:00"}