{"created":"2023-07-27T06:56:33.751063+00:00","id":53410,"links":{},"metadata":{"_buckets":{"deposit":"7064b0f1-34ce-4f38-8e4d-77ad01bfb989"},"_deposit":{"created_by":18,"id":"53410","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53410"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053410","sets":["2812:2813:2819"]},"author_link":["94742"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"今回我々は、IgG4関連疾患患者における耳鼻咽喉科領域の新たな臨床像、嗅覚障害の全貌を明らかにすること、またその背景因子について検討すること、さらにモデルマウスにおいてその実態を検討することを目的として研究を行った。IgG4関連疾患患者に嗅覚検査を施行したところ一般的な成人に対し、非常に高い割合で嗅覚障害を認めた。その背景因子については、アレルギー性鼻炎、副鼻腔炎、病変の多寡にはよらなかった。また、モデルマウスにおいても嗅覚障害が発現していることを行動実験によって証明した。マウスの嗅上皮は特異的な変化は見られず、ターンオーバーの障害が原因と考えられた。今後は上流の調節機構の解明が必要である。","subitem_description_type":"Abstract"},{"subitem_description":"IgG4-related disease (IgG4-RD) is a newly recognized systemic disease. However, little is known about the sinonasal manifestations. This study examined the prevalence of and etiology of olfactory impairment in patients with IgG4-RD by analyzing its clinical features. We also examined the olfactory function of IgG4-RD model mice to investigate the mechanisms underlying olfactory dysfunction. About half of the patients with IgG4-RD presented with moderate to severe olfactory dysfunction. Olfactory dysfunction is a potentially important manifestation of this disease. We examined the IgG4-RD model mice to investigate the mechanisms underlying olfactory dysfunction. Olfactory behavioral testing revealed that the model mice showed mild to moderate olfactory dysfunction. Histological analysis showed that there was no typical pathological finding of IgG4-RD in the olfactory epithelium. The function of newly differentiated and mature olfactory nerve cells were both impaired.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24791760, 研究期間(年度):2012-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「IgG4関連疾患における耳鼻咽喉科領域からの病態解析アプローチ」課題番号24791760\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791760/24791760seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059693","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=40532180"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=40532180","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791760"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791760","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791760/24791760seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791760/24791760seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-19"}],"displaytype":"detail","filename":"HO-PR-NAKANISHI-S-kaken 2015-4p.pdf","filesize":[{"value":"321.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NAKANISHI-S-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53410/files/HO-PR-NAKANISHI-S-kaken 2015-4p.pdf"},"version_id":"d74f5a13-6093-45cd-8247-c9ce618fd7a6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"IgG4関連疾患における耳鼻咽喉科領域からの病態解析アプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IgG4関連疾患における耳鼻咽喉科領域からの病態解析アプローチ"},{"subitem_title":"Clinical and pathological analysis of the sinonasal involvement in IgG4-related disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-19"},"publish_date":"2020-10-19","publish_status":"0","recid":"53410","relation_version_is_last":true,"title":["IgG4関連疾患における耳鼻咽喉科領域からの病態解析アプローチ"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:40:47.510225+00:00"}