{"created":"2023-07-27T06:56:33.796291+00:00","id":53411,"links":{},"metadata":{"_buckets":{"deposit":"a933ba0e-ee1a-4c20-9c40-de7f08c4d12b"},"_deposit":{"created_by":18,"id":"53411","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53411"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053411","sets":["2812:2813:2820"]},"author_link":["22208","94743"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugimoto, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"22208","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70621837","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70621837"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"エピジェネティック制御と男性不妊症との関係に関するエビデンスは増えている。今回我々は、プロモーター領域にTDMR（組織特異的メチル化可変領域）をもつGTF2A1L遺伝子に注目して研究を行った。86症例の非閉塞性無精子症の中で17症例がhypospermatogenesisの組織型であった。この中で、5例がTDMRの高メチル化群、12例が低メチル化群であった。TDMRの高メチル化は、GTF2A1L遺伝子発現の低下と関連していた。しかし、両群とも精子回収率、受精率、妊娠率、出生率に関して比較的好成績であり、GTF2A1L遺伝子発現の異常は妊娠率へは影響を与えていなかった。","subitem_description_type":"Abstract"},{"subitem_description":"The GTF2A1L gene promoter contains the DNA methylation site of a tissue-specific differentially methylated region (TDMR). Eighty-six patients with non-obstructive azoospermia were assessedfor the DNA methylation state of CpG islands in the GTF2A1L promoter using testicular genomic DNA. Based on histological criteria, 17 of the 86 patients had hypospermatogenesis. Patients with hypospermatogenesis were divided into two subgroups: high DNA methylation(HM, n=5) and low DNA methylation (LM, n=12). The GTF2A1L TDMR methylation rate differed significantly between the HM and LM groups (P=0.0019), and GTF2A1L expression was significantly higher among the LM than in the HM patients (P=0.023). High TDMR methylation was correlated with low GTF2A1L gene expression levels. Both groups demonstrated relatively good outcomes with respect to sperm retrieval, fertilisation, pregnancy and childbirth rates. We observed that aberrant GTF2A1L gene expression was not correlated with fertilisation rates.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24791638, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「DNAメチル化異常による精子形成障害と不妊治療に及ぼす影響」研究成果報告書　課題番号24791638\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791638/24791638seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059694","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70621837"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70621837","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791638"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791638","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791638/24791638seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791638/24791638seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉本, 和宏"}],"nameIdentifiers":[{"nameIdentifier":"94743","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70621837","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70621837"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-16"}],"displaytype":"detail","filename":"ME-PR-SUGIMOTO-K-kaken 2014-4p.pdf","filesize":[{"value":"115.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SUGIMOTO-K-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53411/files/ME-PR-SUGIMOTO-K-kaken 2014-4p.pdf"},"version_id":"03577f77-1264-490a-97b7-228d8d25fc3b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DNAメチル化異常による精子形成障害と不妊治療に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNAメチル化異常による精子形成障害と不妊治療に及ぼす影響"},{"subitem_title":"Spermatogenesis disturbance due to aberrant DNA methylation and its impact on fertility treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-16"},"publish_date":"2020-10-16","publish_status":"0","recid":"53411","relation_version_is_last":true,"title":["DNAメチル化異常による精子形成障害と不妊治療に及ぼす影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:51:58.775775+00:00"}