{"created":"2023-07-27T06:56:33.841699+00:00","id":53412,"links":{},"metadata":{"_buckets":{"deposit":"1ad3795f-1484-44cf-a28a-8e6627235151"},"_deposit":{"created_by":18,"id":"53412","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53412"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053412","sets":["2812:2813:2820"]},"author_link":["94744","20093"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自家脂肪組織から容易に作成可能である脂肪由来再生細胞を延長仮骨に移植することで，仮骨延長法での骨成熟の促進が可能であるかを検討した．６０匹のラットを３群に分け，骨延長終了時に生理食塩水を投与したコントロール群，コラーゲンゲルのみを投与したコラーゲンゲル群，脂肪由来再生細胞とコラーゲンゲルを投与したADRC群を作成した．\n移植後６週のADRC群の延長仮骨骨密度は，コントロール群と比較し46%上昇し，骨折強度は66%上昇した．ADRC群の延長仮骨内では，BMP-2，VEGF，SDF-1のRNA量が増加していた．細胞ラベリングでは移植したADRCの骨組織への分化が示唆された","subitem_description_type":"Abstract"},{"subitem_description":"The question of this study was whether uncultured adipose-derived regenerative cells(ADRCs), which can easily be isolated from autologous adipose tissue and contain several types of stem and regenerative cells, promote bone formation in distraction osteogenesis. Sixty rats were randomly assigned to 3 groups. Physiological saline (control group), Type I collagen gel, or a mixture of ADRC and Type I collagen gel (ADRC group) was injected into the distracted callus immediately after distraction termination.\nThe bone density of the distracted callus in the ADRC group increased by 46% compared with the control group at 6 weeks after injection. The fracture strength in the ADRC group increased by 66% compared with the control group at 6 weeks after injection. Real-time PCR of the distracted callus from the ADRC group had higher levels of BMP-2, VEGF A, and SDF-1. Cell labeling in the newly formed bone showed the ADRCs differentiated into osseous tissue at 3 weeks after injection.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24791529, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「自己脂肪由来幹細胞移植による骨再生促進とそのメカニズムの解析」研究成果報告書　課題番号24791529\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791529/24791529seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059695","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90584839"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90584839","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791529"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791529","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791529/24791529seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791529/24791529seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-16"}],"displaytype":"detail","filename":"ME-PR-WATANABE-K-kaken 2014-4p.pdf","filesize":[{"value":"181.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WATANABE-K-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53412/files/ME-PR-WATANABE-K-kaken 2014-4p.pdf"},"version_id":"b2f503c3-edb0-433d-bf8d-4308301c9d10"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自己脂肪由来幹細胞移植による骨再生促進とそのメカニズムの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自己脂肪由来幹細胞移植による骨再生促進とそのメカニズムの解析"},{"subitem_title":"Uncultured Autogenous Adipose-derived Regenerative Cells Promote Bone Formation During Distraction Osteogenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-16"},"publish_date":"2020-10-16","publish_status":"0","recid":"53412","relation_version_is_last":true,"title":["自己脂肪由来幹細胞移植による骨再生促進とそのメカニズムの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:27.569995+00:00"}