{"created":"2023-07-27T06:56:33.887990+00:00","id":53413,"links":{},"metadata":{"_buckets":{"deposit":"6d9f549b-61f6-468b-b8c3-a180ca8a2364"},"_deposit":{"created_by":18,"id":"53413","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53413"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053413","sets":["2812:2813:2820"]},"author_link":["94745"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"19例の神経膠腫症例を対象に MR spectroscopyから代謝産物の定量解析を行うLC modelを用いた腫瘍内代謝評価を試みた。主要代謝物であるグルコース、グルタミン酸、GPCにおいてはIDH変異型神経膠腫と非変異型の両群の間に有意な差は認められなかった一方、今回の代謝解析の主眼となるNAAでは、両群に有意な差は認めなかったものの、NAAGでは、非変異群で0.362,変異群では0.237と約35%低下していた。これらの違いは、IDH1変異に伴う細胞内代謝環境の変化を如実に反映している可能性があり、このことから IDH1変異型神経膠腫の術前診断ができる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We analyzed the intratumoral metabolism of 19 glioma samples using the LC model that  the third party software which can calculate quantitative MR spectrum value of each metabolites. We especially focused on citric acid related metabolites including N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG). Major metabolites in glial cells such as glucose, glutamate acid, GPC did not indicate significant change between IDH-mutated and wild-type glioma. NAA also did not indicate significant differences, whereas NAAG indicated 0.237 (35% reduction) in IDH-mutated glioma comparison to 0.362 in wild type glioma, suggesting that metabolic environment in glioma cells were significantly changed between IDH-mutated and wild-type glioma. Pre-operative MR analysis of glioma using LC model has the possibility of differential  diagnosis of IDH-mutated glioma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24791490, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「IDH変異型神経膠腫群におけるクエン酸サイクルの役割」研究成果報告書　課題番号24791490\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791490/24791490seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059696","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90399775"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90399775","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791490"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791490","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791490/24791490seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791490/24791490seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-16"}],"displaytype":"detail","filename":"ME-PR-WATANABE-T-kaken 2014-4p.pdf","filesize":[{"value":"237.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WATANABE-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53413/files/ME-PR-WATANABE-T-kaken 2014-4p.pdf"},"version_id":"c622fc9e-8966-4808-881a-208fdf5d3449"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"IDH変異型神経膠腫群におけるクエン酸サイクルの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IDH変異型神経膠腫群におけるクエン酸サイクルの役割"},{"subitem_title":"The role of citric acid cycle and related metabolites in IDH1-mutated gliomas","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-16"},"publish_date":"2020-10-16","publish_status":"0","recid":"53413","relation_version_is_last":true,"title":["IDH変異型神経膠腫群におけるクエン酸サイクルの役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:24.600166+00:00"}