{"created":"2023-07-27T06:56:33.933539+00:00","id":53415,"links":{},"metadata":{"_buckets":{"deposit":"d62e4e47-7fe7-42bb-bb7a-b7d8132c1e32"},"_deposit":{"created_by":18,"id":"53415","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53415"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053415","sets":["2812:2813:2820"]},"author_link":["549","85178"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝細胞癌において、肝特異性MRI造影剤Gd-EOB-DTPAはトランスポーターOATP8により細胞に取り込まれる。肝細胞癌ではOATP8の発現低下によりGd-EOB-DTPA造影MRI肝細胞相で通常低信号を示すが、10-15％の頻度でOATP8の発現が亢進し高信号を示す一群が存在する。我々はこのような信号強度の差が特定の分子病理学的背景を有するsubtypeの違いを反映していると推測し、その生物学的特徴の比較検討を行った。その結果、高信号肝癌は低信号肝癌と比較して悪性度が低く予後良好な一群であり、マーカー発現パターンより成熟肝細胞に近い性質を有するsubtypeである可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"On the hepatobiliary phase of Gd-EOB-DTPA enhanced MR imaging (EOB-MRI), hepatocellular carcinoma (HCC) commonly shows hypointensity, however, a part of HCCs demonstrates hyperintensity caused by over-expression of OATP8, the uptake transporter of Gd-EOB-DTPA. We analyzed the correlation between the biological features and signal intensity on EOB-MRI in surgically resected HCC.\nHyperintense HCC showed significantly less malignant biological features and better prognosis than those of hypointense HCC. Hyperintense HCC, namely OATP8 over-expressed HCC, is supposed to be a subtype with mature hepatocyte like molecular backgrounds.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24791281, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝細胞癌のGd-EOB-DTPA造影MRIによるsubtype分類」研究成果報告書　課題番号24791281\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791281/24791281seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059698","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20608690"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20608690","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791281"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791281","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791281/24791281seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791281/24791281seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-16"}],"displaytype":"detail","filename":"HO-PR-KITAO-A-kaken 2014-5p.pdf","filesize":[{"value":"474.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KITAO-A-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53415/files/HO-PR-KITAO-A-kaken 2014-5p.pdf"},"version_id":"589c7a20-1660-441b-baab-bd8c417f39a3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌のGd-EOB-DTPA造影MRIによるsubtype分類","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌のGd-EOB-DTPA造影MRIによるsubtype分類"},{"subitem_title":"Subtype classification of hepatocellular carcinoma by Gd-EOB-DTPA enhanced magnetic resonance imaging","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-16"},"publish_date":"2020-10-16","publish_status":"0","recid":"53415","relation_version_is_last":true,"title":["肝細胞癌のGd-EOB-DTPA造影MRIによるsubtype分類"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:26.291452+00:00"}