{"created":"2023-07-27T06:56:34.114950+00:00","id":53419,"links":{},"metadata":{"_buckets":{"deposit":"4ec3ac22-a842-4725-bf56-839dc06b0546"},"_deposit":{"created_by":18,"id":"53419","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53419"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053419","sets":["2812:2813:2820"]},"author_link":["94751","22653"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"B型慢性肝炎では、肝細胞癌でのAP1発現と、背景肝のDNA損傷応答関連遺伝子発現間に直接相互作用を認めた。また、癌部におけるAP1発現は、癌部で発現亢進する多くの遺伝子と直接相互作用を有していた。一方、C型慢性肝炎では背景肝でのSTAT1およびPTEN発現は、癌部での血管新生、線維形成、および腫瘍形成促進遺伝子である、EGR1およびFAK1発現を抑制していた。リアルタイムPCRでの検証では、発癌時点での背景肝におけるSTAT1およびPTEN発現は、発癌以前と比較し低下していた。マイクロRNAでの検証では肝癌発癌における発現変化の検証をし、以前の報告を確認しえた。","subitem_description_type":"Abstract"},{"subitem_description":"DNA damage response genes in non-tumor lesions were associated with AP1 signaling which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducers and activators of transcription 1 and phosphatase and tensin homolog in non-tumor lesions were associated with early growth response protein 1 signaling that potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC. MicroRNAs were up- or down-regulated in cancerous tissue. These expression changes were confirmed as previously.\nGene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24790686, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ウイルス性慢性肝疾患からの発癌に関わるマイクロRNAの探索」研究成果報告書　課題番号24790686\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24790686/24790686seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059702","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80600741"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80600741","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24790686"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24790686","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24790686/24790686seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24790686/24790686seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-16"}],"displaytype":"detail","filename":"ME-PR-UEDA-T-kaken 2014-4p.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-UEDA-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53419/files/ME-PR-UEDA-T-kaken 2014-4p.pdf"},"version_id":"6c673a16-c8ee-4842-9d47-479c5a69273a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ウイルス性慢性肝疾患からの発癌に関わるマイクロRNAの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウイルス性慢性肝疾患からの発癌に関わるマイクロRNAの探索"},{"subitem_title":"Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-16"},"publish_date":"2020-10-16","publish_status":"0","recid":"53419","relation_version_is_last":true,"title":["ウイルス性慢性肝疾患からの発癌に関わるマイクロRNAの探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:13:19.236346+00:00"}