{"created":"2023-07-27T06:56:37.878231+00:00","id":53505,"links":{},"metadata":{"_buckets":{"deposit":"09ee68a9-b84f-4f93-b084-c9b3922c3330"},"_deposit":{"created_by":18,"id":"53505","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53505"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053505","sets":["2812:2813:2823"]},"author_link":["344"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008 – 2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究はスギヒラタケ脳症が複数の毒性原因に基づくと仮定して検証を進め、これまでに得られた内臓障害性および炎症性を示すペプチジルポリシアル酸類縁体の精製と構造解析の結果、スギヒラタケの糖タンパクには、ヒト体内で抗原性を示すN-グリコリルノイラミン酸(NeuGc)が特異的に含まれていることを明らかにし、スギヒラタケ脳症への関与を示唆した。一方、腸管上皮細胞障害性と神経組織への障害性が考えられる低分子成分であるスフィンゴ糖脂質の絶対構造を決定し化学合成を行った。","subitem_description_type":"Abstract"},{"subitem_description":"This study was focused on the supposition that Angel Wing (Pleurocybella porrigens) brain disorder was based on plural toxic causes. The refinement and the structural analysis of the peptidyl polysialic analogues having internal organs disorder characteristics and inflammatory nature showed that N-glycolyl neuraminic acid (NeuGc) indicating the antigenicity was specifically included in the glycoprotein of the Angel Wing. On the other hand, the structure of sphingoglycolipid A was determined and synthesized. Sphingoglycolipid A was presumed on impaired characteristics to the nervous system and intestinal epithelia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20590004, 研究期間(年度):2008 – 2010\n","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「急性脳症を誘発するスギヒラタケの脳症起因物質の探索」課題番号20590004\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590004/20590004seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059787","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50108560"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50108560","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20590004/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20590004/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590004/20590004seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590004/20590004seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-26"}],"displaytype":"detail","filename":"PH-PR-OHTA-T-kaken 2011-4p.pdf","filesize":[{"value":"242.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-OHTA-T-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53505/files/PH-PR-OHTA-T-kaken 2011-4p.pdf"},"version_id":"000d4908-dd55-4563-8cc3-377f35d949e4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"急性脳症を誘発するスギヒラタケの脳症起因物質の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"急性脳症を誘発するスギヒラタケの脳症起因物質の探索"},{"subitem_title":"Study of encephalopathy inducing constituent in Pleurocybella porrigens","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-26"},"publish_date":"2020-11-26","publish_status":"0","recid":"53505","relation_version_is_last":true,"title":["急性脳症を誘発するスギヒラタケの脳症起因物質の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:23:13.235921+00:00"}