{"created":"2023-07-27T06:56:39.080889+00:00","id":53532,"links":{},"metadata":{"_buckets":{"deposit":"b005734f-48dc-4aea-8217-4c48c5c10e00"},"_deposit":{"created_by":18,"id":"53532","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53532"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053532","sets":["2812:2813:2815"]},"author_link":["69497","2209"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"細胞競: 細胞社会を支える適者生存システム"},{"subitem_alternative_title":"Cell competition: a mechanism for survival of the fittest in the multi-cellular community"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"2017-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 新学術領域研究(研究領域提案型) 研究実績の概要"},{"bibliographic_title":"2018 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"当初SUCLA2のアイソザイムであるSUCLG2の阻害が合成致死性を発揮すると考えたが、その効果は、限定的であった。そこで、我々は、SUCLA2を欠く前立腺がん細胞株とそこにSUCLA2を再構成した前立腺がん細胞株を作成、CRISPR-CAS9ライブラリーを用い、SUCLA2を欠く前立腺がん細胞株において特異的にドロップアウトする代謝遺伝子を検索し、8の候補遺伝子を得た。さらに我々は、SUCLA2欠失前立腺がん特異的に細胞死を誘導する化合物のスクリーニングを行い、現在までに、天然化合物ライブラリーのスクリーニングから、化合物2種がSUCLA2欠失株特異的に細胞傷害性を示すことを明らかにした。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17H05615, 研究期間(年度):2017-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「乳腺上皮・乳がんにおけるRB モザイシズムと細胞競合」課題番号17H05615\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-17H05615/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059814","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50283619"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50283619","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-17H05615/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-17H05615/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-3605/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-3605/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3605/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3605/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-11"}],"displaytype":"detail","filename":"CA-PR-TAKAHASHI-C-kaken 2019-2p.pdf","filesize":[{"value":"174.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TAKAHASHI-C-kaken 2019-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53532/files/CA-PR-TAKAHASHI-C-kaken 2019-2p.pdf"},"version_id":"23a6686c-a6f5-4a0f-be88-dc29b5af3eb7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"乳腺上皮・乳がんにおけるRB モザイシズムと細胞競合","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳腺上皮・乳がんにおけるRB モザイシズムと細胞競合"},{"subitem_title":"RB mosaicism and cell competition in mammary epithelial and cancer cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-11"},"publish_date":"2020-12-11","publish_status":"0","recid":"53532","relation_version_is_last":true,"title":["乳腺上皮・乳がんにおけるRB モザイシズムと細胞競合"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:34:54.696638+00:00"}