{"created":"2023-07-27T06:56:40.433526+00:00","id":53562,"links":{},"metadata":{"_buckets":{"deposit":"298038c0-e519-4e05-969d-f03b4faa3bb9"},"_deposit":{"created_by":18,"id":"53562","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53562"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053562","sets":["2812:2813:2825"]},"author_link":["47956","95404"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2007 – 2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"正常細胞のWnt経路制御作用からがん抑制的に働く機能分子と認識されているglycogen synthase kinase 3β (GSK3β)の大腸がんへの関与に着目した. そして, GSK3βの過剰発現やそのリン酸化による酵素活性調節の破綻ががん細胞の生存や増殖を維持・推進するという, Wnt経路抑制機能とは異なる病的作用を発見した. その後, GSK3β阻害の制がん効果を消化器がん細胞と担がん動物で実証し, 本酵素が新しいがん治療標的であると提唱した. 現在までに, その制がん効果ががん抑制分子経路に依存するという結果をえて, 膵がんや脳悪性腫瘍などの難治性がんに対象を広げて分子機構を解析している.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19790938, 研究期間(年度):2007 – 2008\n","subitem_description_type":"Other"},{"subitem_description":"出典：「GSK3βのがん細胞生存・増殖維持機能の解明と分子標的がん治療法の開発」策定と実践モデルの構築」研究成果報告書　課題番19790938\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19790938/19790938seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059844","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10447659"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10447659","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19790938/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19790938/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19790938/19790938seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19790938/19790938seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-27"}],"displaytype":"detail","filename":"CA-PR-MAI-W-kaken 2009-4p.pdf","filesize":[{"value":"147.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-MAI-W-kaken 2009-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53562/files/CA-PR-MAI-W-kaken 2009-4p.pdf"},"version_id":"423f94ed-7bbb-4713-bc35-c45bbe76c9d2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GSK3βのがん細胞生存・増殖維持機能の解明と分子標的がん治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GSK3βのがん細胞生存・増殖維持機能の解明と分子標的がん治療法の開発"},{"subitem_title":"Molecular basis for developing a strategy of cancer treatment targeting aberrant GSK3β","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-27"},"publish_date":"2020-11-27","publish_status":"0","recid":"53562","relation_version_is_last":true,"title":["GSK3βのがん細胞生存・増殖維持機能の解明と分子標的がん治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:13:04.217304+00:00"}