{"created":"2023-07-27T06:56:42.109233+00:00","id":53600,"links":{},"metadata":{"_buckets":{"deposit":"81df9227-1c23-432d-bac1-eaa35e024b5d"},"_deposit":{"created_by":18,"id":"53600","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53600"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053600","sets":["2812:2813:2821"]},"author_link":["95234","83498"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011 – 2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miwa, Sotarou"}],"nameIdentifiers":[{"nameIdentifier":"83498","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80507070","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80507070"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SPARC(Secreted Protein and Rich in Cysteine, オステオネクチン)は細胞外マトリックスタンパク質である。この前立腺癌での作用を明らかにした。SPARCの発現が前立腺癌由来間質細胞で低下していた。SPARCがAKTのリン酸化の阻害をすることによって前立腺癌細胞の増殖、及び遊走能を阻害した。これらのSPARCの作用は、SPARCがインテグリンβ1に直接結合した後に作用することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"SPARC (Secreted Protein and Rich in Cysteine, osteonectin) is extracellular matrix protein. We identified effects of SPARC on prostate cancer.Expression of SPARC decreased with stromal cells derived from prostate cancer. SPARC inhibited the proliferation of prostate cancer cells and migrating ability by inhibiting the phosphorylation of AKT. It came to light that the effects of these SPARC acted after SPARC bound to integrin beta 1 directly.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23791747, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「前立腺癌骨転移とオステオネクチンの関連についての研究」課題番号23791747\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791747/23791747seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059882","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80507070"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80507070","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791747/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791747/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791747/23791747seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791747/23791747seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三輪, 聰太郎"}],"nameIdentifiers":[{"nameIdentifier":"95234","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80507070","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80507070"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-20"}],"displaytype":"detail","filename":"ME-PR-MIWA-S-kaken 2013-4p.pdf","filesize":[{"value":"554.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIWA-S-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53600/files/ME-PR-MIWA-S-kaken 2013-4p.pdf"},"version_id":"b54dc6c0-c6dc-4ae4-850d-fae307f1fa57"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"前立腺癌骨転移とオステオネクチンの関連についての研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"前立腺癌骨転移とオステオネクチンの関連についての研究"},{"subitem_title":"The effect of osteonection on prostate cancer and bone metastasis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-20"},"publish_date":"2020-11-20","publish_status":"0","recid":"53600","relation_version_is_last":true,"title":["前立腺癌骨転移とオステオネクチンの関連についての研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:55:25.899808+00:00"}