{"created":"2023-07-27T06:56:42.333952+00:00","id":53605,"links":{},"metadata":{"_buckets":{"deposit":"4bf6dbd2-dac7-464e-a994-8651d19bddfc"},"_deposit":{"created_by":18,"id":"53605","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53605"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053605","sets":["2812:2813:2819"]},"author_link":["95239","47629"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011 – 2012","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HGF-cMetシグナルのON-OFF調節メカニズムは長らく不明であった.cMet-Ser985のリン酸化が、細胞膜表面に存在するcMetの細胞内への吸収を調節することで、HGF依存的なシグナル発信を抑制することを明らかにした.さらに、cMetの生物活性は二量体化されたときにのみ発現され、モノマーの場合はたとえ強いリン酸化が引き起こされていても決して発揮されないことを明らかにした.","subitem_description_type":"Abstract"},{"subitem_description":"Regulation mechanisms of the ON-OFF conversion of the HGF-cMetsignal had remained to be clarified. We found that phosphorylation of the cMet-Ser985was involved in suppression of the HGF-dependent cMet bioactivity through internalization of the cMet intracellularly from the cell surface. Moreover, we found that cMet exerts its biological activities only when they were dimer, and never exerts when monomer, even if strongly phosphorylated.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23790327, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「cMet/HGF受容体ON-OFF機能変換を介した再生・病態・発癌制御の研究」課題番号23790327\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790327/23790327seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059887","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70414018"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70414018","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790327/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790327/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790327/23790327seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790327/23790327seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-20"}],"displaytype":"detail","filename":"CA-PR-NAKAMURA-T-kaken 2013-4p.pdf","filesize":[{"value":"342.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-NAKAMURA-T-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53605/files/CA-PR-NAKAMURA-T-kaken 2013-4p.pdf"},"version_id":"851cff8b-151e-41e4-bcd5-4c5aed2263a4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"cMet/HGF受容体ON-OFF機能変換を介した再生・病態・発癌制御の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"cMet/HGF受容体ON-OFF機能変換を介した再生・病態・発癌制御の研究"},{"subitem_title":"Regulation of regeneration, disease and carcinogenesis throughthe ON-OFF conversion of the cMet/HGF receptor.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-20"},"publish_date":"2020-11-20","publish_status":"0","recid":"53605","relation_version_is_last":true,"title":["cMet/HGF受容体ON-OFF機能変換を介した再生・病態・発癌制御の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:41:28.494506+00:00"}