{"created":"2023-07-27T06:56:42.602696+00:00","id":53611,"links":{},"metadata":{"_buckets":{"deposit":"f770e468-465b-4547-93e9-d5700ba2cb64"},"_deposit":{"created_by":18,"id":"53611","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53611"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053611","sets":["2812:2813:2821"]},"author_link":["47750","95245"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011 – 2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がん抑制遺伝子Rbの不活性化は、がんの悪性進展過程において頻繁に観察される。これまでに私達は、p53が欠損したがん細胞において、Rbの不活性化により、がん幹細胞様細胞が出現することを明らかにした。RNA sequenceにより遺伝子発現を解析した結果、Rb不活性化により誘導されるがん幹細胞様細胞群では炎症性サイトカインの発現が亢進していることが明らかになった。さらに遺伝子ノックダウン実験から、これら炎症性サイトカインの分泌さらにその下流のSTAT3活性化が、Rb不活性化によるがん幹細胞様細胞の誘導と炎症性がん微小環境の形成に寄与することが明らかになった。これは、Rb不活性化が、がん細胞の幹細胞性獲得というCell autonomousな作用のみならず、Non-cell autonomousな作用を介して、がんの悪性化を促進することを意味する。","subitem_description_type":"Abstract"},{"subitem_description":"Inactivation of Rb is frequently found during tumor progression. We found that Rb inactivation in p53 null background contributes to the acquisition of cancer stemness. RNA sequence analysis revealed that these cells exhibited signatures of inflammatory conditions. Knockdown experiments showed that sphere-forming activity induced by Rb depletion depend on activation of IL6 -STAT3 axis. Moreover, it seems that activation of STAT3 pathway induced by Rb inactivation directly cause an inflammatory tumor environment. These results are expected to provide some new insights into cell autonomous and non-cell autonomous function of Rb during tumor progression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23701048, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「癌進展過程における癌幹細胞様細胞の出現をpRbが抑制する」課題番号23701048\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23701048/23701048seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059893","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90566465"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90566465","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701048/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701048/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23701048/23701048seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23701048/23701048seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-20"}],"displaytype":"detail","filename":"CA-PR-KITAJIMA-S-kaken 2013-4p.pdf","filesize":[{"value":"327.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-KITAJIMA-S-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53611/files/CA-PR-KITAJIMA-S-kaken 2013-4p.pdf"},"version_id":"b2453571-4754-482d-ae64-3055ef9f4c05"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌進展過程における癌幹細胞様細胞の出現をpRbが抑制する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌進展過程における癌幹細胞様細胞の出現をpRbが抑制する"},{"subitem_title":"Undifferentiated state induced by Rb inactivation associated with activation of inflammatory signaling","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-20"},"publish_date":"2020-11-20","publish_status":"0","recid":"53611","relation_version_is_last":true,"title":["癌進展過程における癌幹細胞様細胞の出現をpRbが抑制する"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:27:59.023749+00:00"}