{"created":"2023-07-27T06:56:43.721422+00:00","id":53639,"links":{},"metadata":{"_buckets":{"deposit":"07e1be27-8fef-4a7b-9b08-1469e6744c50"},"_deposit":{"created_by":18,"id":"53639","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53639"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053639","sets":["2812:2813:2825"]},"author_link":["69343"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2007 – 2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"医薬品の薬効・毒性への影響が大きい肝動態を決める、肝有機アニオン輸送体の種差に関する研究を行なった。特にOATP と呼ばれるは輸送体はヒト動物とも肝臓に複数のサブタイプが発現しており、種間の対応付けが不明であった。そこで、ヒトOATP とラットOatp 発現系、さらに両種からの肝細胞、ラット全身動態試験を行ない、機能的に対応する分子の同定を試みた。その結果、β-ラクタム抗生物質については、ヒトOATP1B3 とラットoatp1a4 が両種間機能的に対応する分子であることが示された。両者は遺伝子・アミノ酸配列として相同性が高くないため、動物の薬物動態データからヒト予測を行なうためには、タンパク質構造のみならず機能解析も行なう必要性を示し、今後の医薬品の開発・臨床適用における有用な知見を得ることが出来た。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19390046, 研究期間(年度):2007 – 2008","subitem_description_type":"Other"},{"subitem_description":"出典：「有機アニオン輸送体を介した薬物の肝移行性調節とその種差」研究成果報告書　課題番号19390046\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19390046/19390046seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系 / 東京理科大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059921","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20155237"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20155237","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19390046/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19390046/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19390046/19390046seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19390046/19390046seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-30"}],"displaytype":"detail","filename":"PH-PR-TAMAI-I-kaken 2009-5p.pdf","filesize":[{"value":"37.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-TAMAI-I-kaken 2009-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53639/files/PH-PR-TAMAI-I-kaken 2009-5p.pdf"},"version_id":"1cf1b3b0-bf49-434a-b73b-ef5aaccd3104"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"有機アニオン輸送体を介した薬物の肝移行性調節とその種差","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"有機アニオン輸送体を介した薬物の肝移行性調節とその種差"},{"subitem_title":"Species difference in hepatic disposition of organic anions","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-30"},"publish_date":"2020-11-30","publish_status":"0","recid":"53639","relation_version_is_last":true,"title":["有機アニオン輸送体を介した薬物の肝移行性調節とその種差"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:11:42.312761+00:00"}