{"created":"2023-07-27T06:56:44.885347+00:00","id":53666,"links":{},"metadata":{"_buckets":{"deposit":"d7bf7716-0b2a-4509-beb4-782e4876857b"},"_deposit":{"created_by":18,"id":"53666","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53666"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053666","sets":["2812:2813:2818"]},"author_link":["2913"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"グリアアセンブリによる脳機能発現の制御と病態"},{"subitem_alternative_title":"Glial assembly: a new regulatory machinery of brain function and disorders"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"2014-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 新学術領域研究(研究領域提案型) 研究実績の概要"},{"bibliographic_title":"2015 Research Project Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"グリア病である神経障害性疼痛は、精神的ストレスや精神疾患との関連性が臨床上指摘されている（うつを伴う慢性痛、統合失調症や自閉スペクトラム症での痛覚鈍麻など）。しかし、この「精神と疼痛(痛み)」の関連性（連関）の分子基盤は未解明である。\n\n我々の解析結果より、睡眠障害等の精神疾患との関連性が深い体内時計システムが破綻したマウスでは、行動・疼痛機能の異常とともに、脳・脊髄組織でのアストロサイトでの異常活性化が認められる。これにより、血管周囲に存在するアストロサイト-ペリサイトアセンブリが異常をきたす可能性を提唱した。つまり、BBB恒常性は体内時計システムによるグリアネットワークの上に成り立つことを示唆するものである。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26117507, 研究期間(年度):2014-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明」課題番号26117507\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-26117507/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059948","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=30377428"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=30377428","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-26117507/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-26117507/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-3507/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-3507/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3507/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3507/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-17"}],"displaytype":"detail","filename":"PH-PR-TAKARADA-T-kaken 2018-2p.pdf","filesize":[{"value":"158.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-TAKARADA-T-kaken 2018-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53666/files/PH-PR-TAKARADA-T-kaken 2018-2p.pdf"},"version_id":"ba81f4f5-193a-4b57-8219-4e5aec26a0b3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-17"},"publish_date":"2020-12-17","publish_status":"0","recid":"53666","relation_version_is_last":true,"title":["体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:53:35.261042+00:00"}