{"created":"2023-07-27T06:56:45.647153+00:00","id":53683,"links":{},"metadata":{"_buckets":{"deposit":"2d16593c-4717-474e-8e31-bb836441efc9"},"_deposit":{"created_by":18,"id":"53683","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53683"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053683","sets":["2812:2813:2815"]},"author_link":["83","74347"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"細胞死を起点とする生体制御ネットワークの解明"},{"subitem_alternative_title":"Molecular mechanisms and roles of pyroptosis"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-07-10 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 新学術領域研究(研究領域提案型) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では当初、カスパーゼ1誘導プログラム細胞死であるパイロトーシスの分子機構と役割の解明を目指した。最近、パイロトーシス実行蛋白GSDMDが同定されたが、GSDMD欠損細胞でもカスパーゼ1依存性細胞死が誘導される。この細胞死の分子機構を解析し、GSDMD欠損細胞や、元々GSDMDの発現が低い神経細胞やマスト細胞ではカスパーゼ1がBid依存性アポトーシスを誘導することを示した（Nat Commun, 2019）。また、がん治療モデルを用い、がん細胞にパイロトーシスを誘導するとアポトーシスを誘導した場合よりも強い抗腫瘍免疫を誘導しうることを示した。","subitem_description_type":"Abstract"},{"subitem_description":"This study aimed to clarify molecular mechanisms and roles of caspase-1-meidated cell death. Recent studies identified gasdermin D (GSDMD) as the effector molecule of pyroptosis, a caspase-1-dependent inflammatory cell death. However, GSDMD-deficient macrophages are still susceptible to caspase-1 activation. Thus, we investigated the molecular mechanism of caspase-1-dependent GSDMD-independent cell death. We found that GSDMD-deficient cells exhibits Bid-dependent apoptosis in response to caspase-1 activation. We found the same for inherently GSDMD-null/low cells such as neuronal cells and mast cells. These findings may contribute to understanding of the mechanism of caspase-1-related diseases such as neurodegenerative diseases. In addition, we demonstrated that pyroptotic cell death of tumor cells induces stronger anti-tumor immune responses than apoptotic cell death in an animal tumor therapy model. The latter finding may help to develop novel strategy of cancer therapy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26110002, 研究期間(年度):2014-07-10 – 2019-03-31\n","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059965","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70250090"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70250090","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-26110002/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-26110002/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PLANNED-26110002/26110002seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PLANNED-26110002/26110002seika/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-3601/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-3601/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3601/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3601/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-30"}],"displaytype":"detail","filename":"CA-PR-SUDA-T-kaken 2019-6p.pdf","filesize":[{"value":"89.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUDA-T-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53683/files/CA-PR-SUDA-T-kaken 2019-6p.pdf"},"version_id":"143a0453-d0c4-465d-9948-d375687bba5c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"パイロトーシスの分子機構と役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パイロトーシスの分子機構と役割"},{"subitem_title":"Molecular mechanisms and roles of pyroptosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-30"},"publish_date":"2020-11-30","publish_status":"0","recid":"53683","relation_version_is_last":true,"title":["パイロトーシスの分子機構と役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:28:18.342644+00:00"}