{"created":"2023-07-27T06:56:46.411026+00:00","id":53700,"links":{},"metadata":{"_buckets":{"deposit":"27282340-2b1a-479d-a9cc-8fd99b41d5ef"},"_deposit":{"created_by":18,"id":"53700","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53700"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053700","sets":["2812:2813:2824"]},"author_link":["2900"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008 – 2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々が作製したHP1γの変異マウスは雌雄ともに不妊であったので、その原因について研究を行った。その結果、減数分裂の開始時期にセントロメア近傍領域の集積が認められないこと、及び、野生型精原細胞において集積のみられるヒストンメチル化酵素がHP1γ変異マウスの精原細胞では集積できないことがわかり、これらのことから、HP1γはセントロメア近傍におけるヒストン修飾因子のリクルートに必須であり、減数分裂の正常な進行にはセントロメアのヒストン修飾が必要であることが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"We obtained HP1 gamma mutant mice and found that all homozygous mice were infertile as a result of defects in meiosis. Some kinds of histone methylation at pericentromeric heterochromatin were reduced in the mutant spermatocytes and spermatogonia. Moreover, a methyltransferase of H3K9 in spermatocytes could not accumulate in the mutant spermatocytes. These findings suggest that HP1 gamma is essential for recruitment of histone modification factors at pericentromeric heterochromatin and histone modifications are required for progression of meiosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20700363, 研究期間(年度):2008 – 2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヘテロクロマチンプロテイン1γ変異マウスが不妊症を呈する分子メカニズムの解析」課題番号20700363\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20700363/20700363seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059982","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20700363"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20700363","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20700363/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20700363/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20700363/20700363seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20700363/20700363seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-30"}],"displaytype":"detail","filename":"FR-PR-NARUSE-C-kaken 2010-4p.pdf","filesize":[{"value":"198.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-NARUSE-C-kaken 2010-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53700/files/FR-PR-NARUSE-C-kaken 2010-4p.pdf"},"version_id":"f7fbbf87-854a-4598-a810-086c04eae962"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヘテロクロマチンプロテイン1γ変異マウスが不妊症を呈する分子メカニズムの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヘテロクロマチンプロテイン1γ変異マウスが不妊症を呈する分子メカニズムの解析"},{"subitem_title":"Analyses of infertility of HP1γ mutant mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-30"},"publish_date":"2020-11-30","publish_status":"0","recid":"53700","relation_version_is_last":true,"title":["ヘテロクロマチンプロテイン1γ変異マウスが不妊症を呈する分子メカニズムの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:12:16.074216+00:00"}