{"created":"2023-07-27T06:56:50.848991+00:00","id":53802,"links":{},"metadata":{"_buckets":{"deposit":"5b768d96-bdb9-483a-9104-c13ac882d35f"},"_deposit":{"created_by":18,"id":"53802","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53802"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053802","sets":["934:935:937"]},"author_link":["15540","15084"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"832","bibliographicPageStart":"825","bibliographicVolumeNumber":"99","bibliographic_titles":[{"bibliographic_title":"The Journal of Biochemistry"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"板垣, 英治"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A steroid monooxygenase of Cylindrocarpon radicicola was found to catalyze oxygenative lactonization of 17α-etosteroid, androstenedione, to yield D-hmo-17α-oxasteroid, testololactone, i.e., the androstenedione monooxygenase reaction, in addition to catalyzing the progesterone monooxygenase reaction. The reaction product was identified by TLC, GLC, and mass spectrometry.\nThe oxygenation proceeded with unitary stoichiometry for 17-ketosteroid, NADPH, and molecular oxygen, indicating that it is a typical monooxygenase reaction of the external electron donor type. The enzyme catalyzed successively the side chain cleavage reaction of 17α-hydroxy-20-ketosteroid to produce its 17-ketoerivative and the lactonization of the product.\nThe effects of pH and of the concentration of substrate steroids on the androstenedione monooxygenase reaction were different from those on the progesterone onooxygenase reaction. Progesterone is a strong and competitive inhibitor of he lactonization of 17-ketosteroids. The steroid monooxygenase is concluded to ave the activities of both oxygenative esterification of 20-ketosteroids and oxygenative lactonization of 17-ketosteroids.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00060083","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Biochemical Society"}]},"item_4_publisher_19":{"attribute_name":"出版者(別名)","attribute_value_mlt":[{"subitem_publisher":"日本生化学会"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.jbsoc.or.jp/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jbsoc.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://academic.oup.com/jb"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/jb","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/biochemistry1922/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/biochemistry1922/-char/ja","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © The Japanese Biochemical Society 日本生化学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00694073","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-924X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Itagaki, Eiji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-03"}],"displaytype":"detail","filename":"SC-PR-ITAGAKI-E-99_825.pdf","filesize":[{"value":"576.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC-PR-ITAGAKI-E-99_825.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53802/files/SC-PR-ITAGAKI-E-99_825.pdf"},"version_id":"b045c1a8-4e09-423e-ab1f-eec8b91a020d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Studies on Steroid Monooxygenase from Cylindrocarpon radicicola ATCC 11011.1 Oxygenative Lactonization of Androstenedione to Testololactone","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Studies on Steroid Monooxygenase from Cylindrocarpon radicicola ATCC 11011.1 Oxygenative Lactonization of Androstenedione to Testololactone"}]},"item_type_id":"4","owner":"18","path":["937"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-03"},"publish_date":"2020-12-03","publish_status":"0","recid":"53802","relation_version_is_last":true,"title":["Studies on Steroid Monooxygenase from Cylindrocarpon radicicola ATCC 11011.1 Oxygenative Lactonization of Androstenedione to Testololactone"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T15:28:07.865372+00:00"}