{"created":"2023-07-27T06:56:55.386375+00:00","id":53919,"links":{},"metadata":{"_buckets":{"deposit":"40460405-3677-451b-809f-ad83c5638207"},"_deposit":{"created_by":18,"id":"53919","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53919"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053919","sets":["2812:2813:2824"]},"author_link":["23919","55"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2005 – 2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 特定領域研究 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"リゾリン脂質メディエータースフィンゴシンー1-リン酸S1Pは受容体ファミリーを介して細胞遊走・浸潤を正負に制御する。この中で細胞遊走・浸潤を負に制御するS1P2は生体では主として血管内皮・平滑筋、骨髄由来細胞に発現する。宿主細胞のS1P_2は腫瘍血管新生を抑制し、転移を抑制する。従来の報告とは異なり、腫瘍細胞および宿主におけるS1P産生酵素sphingosine kinase-1(SK1)の過剰発現は腫瘍進展に寄与しない。腫瘍・宿主のS1P2は新規な治療標的となりうる。","subitem_description_type":"Abstract"},{"subitem_description":"The lysophospholipid mediator sphingosine-1-phosphate (S1P) exerts positive or negative effects on cell migration and invasion via a receptor family. Among these, the S1P receptor type 2, S1P_2, was found to be expressed in vascular endothelial cells, smooth muscle cells, and bone marrow-derived cells. S1P_2 in the host cells suppresses tumor angiogenesis and tumor growth. On the contrary to previous reports, overexpression of the S1P synthesizing enzyme sphingosine kinase-1 in tumor cells or host tissues does not aggravate tumor progression. S1P_2 in tumor cells and host cells are a potential novel therapeutic target for tumors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17014034, 研究期間(年度):2005 – 2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん血行転移を制御するシグナリング機構」課題番号17014034\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17014034/17014034seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00060199","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60171592"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60171592","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17014034/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17014034/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17014034/17014034seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17014034/17014034seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-10"}],"displaytype":"detail","filename":"ME-PR-TAKUWA-Y-kaken 2010-6p.pdf","filesize":[{"value":"232.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKUWA-Y-kaken 2010-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53919/files/ME-PR-TAKUWA-Y-kaken 2010-6p.pdf"},"version_id":"7b2b9a94-b8ff-4581-8c84-dea2be1740db"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん血行転移を制御するシグナリング機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん血行転移を制御するシグナリング機構"},{"subitem_title":"Signaling for regulating hematogenous metastasis of tumors","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-10"},"publish_date":"2020-12-10","publish_status":"0","recid":"53919","relation_version_is_last":true,"title":["がん血行転移を制御するシグナリング機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:12:36.849914+00:00"}