{"created":"2023-07-27T06:56:55.438836+00:00","id":53920,"links":{},"metadata":{"_buckets":{"deposit":"0e2524db-33bd-4765-af58-fc095a9871fe"},"_deposit":{"created_by":18,"id":"53920","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"53920"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00053920","sets":["2812:2813:2824"]},"author_link":["95459","15659"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2005 – 2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 特定領域研究 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がんの組織に生じる新しい血管の形成は、がん細胞への養分や酸素の供給の導線となり、この血管形成が生じる分子機構を解明することで、その制御により新しいがん治療の開発をめざして研究を遂行した。その結果、がん組織の中の最も悪性度の高いがん幹細胞は腫瘍周囲の血管新生抑制剤に抵抗性を示す成熟血管近傍に存在し、この血管の成熟化に、造血幹細胞の血管壁細胞への分化転換、および血管内皮細胞に発現するTie2受容体、APJ受容体の活性化が関わることが判明した。","subitem_description_type":"Abstract"},{"subitem_description":"As newly developed blood vessels in tumor environment supply oxygen and nutrient to cancer cells resulted in growth of tumor, we analyzed the molecular mechanisms of blood vessel formation in cancer to develop a good strategy for inhibition of tumor angiogenesis. We found that cancer stem cells locate near the mature blood vessels in the tumor edge that show resistance against angiogenesis inhibitors. Moreover, we found that maturation of blood vessels in tumor is caused by the transdifferentiation of hematopoietic stem cells into mural cells which support stability of blood vessels and associates with activation of receptors, Tie2 and APJ expressed on endothelial cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17014033, 研究期間(年度):2005 – 2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん組織における血管リモデリング機構」課題番号17014033\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17014033/17014033seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"大阪大学 / 金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00060200","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80291954"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80291954","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17014033/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17014033/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17014033/17014033seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17014033/17014033seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-10"}],"displaytype":"detail","filename":"CA-PR-TAKAHASHI-N-kaken 2010-5p.pdf","filesize":[{"value":"229.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TAKAHASHI-N-kaken 2010-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/53920/files/CA-PR-TAKAHASHI-N-kaken 2010-5p.pdf"},"version_id":"aca3e2b0-b82c-439f-9ffa-e425fcd4959e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん組織における血管リモデリング機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん組織における血管リモデリング機構"},{"subitem_title":"Analysis of blood vessel formation in the tumor environment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-10"},"publish_date":"2020-12-10","publish_status":"0","recid":"53920","relation_version_is_last":true,"title":["がん組織における血管リモデリング機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:12:34.790009+00:00"}