{"created":"2023-07-27T06:56:59.688863+00:00","id":54005,"links":{},"metadata":{"_buckets":{"deposit":"08f6ec70-7ad9-4c03-a800-d127920f2165"},"_deposit":{"created_by":18,"id":"54005","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"54005"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00054005","sets":["2812:2813:4085"]},"author_link":["77802","68205"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"予防を科学する炎症細胞社会学"},{"subitem_alternative_title":"Preventive medicine through inflammation cellular sociology"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"16p.","bibliographicVolumeNumber":"2017-06-30 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 新学術領域研究(研究領域提案型) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{"nameIdentifier":"77802","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60185923","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60185923"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"単純性脂肪肝から非アルコール性肝疾患・肝炎（NAFLD/NASH）の移行において、肝小葉のzoneごとに代謝が変化することが知られている（metabolic zonation）。今回の解析によって、それに伴って肝臓を構成する細胞の発現遺伝子も変化することが明らかとなった。線維化に重要な役割を果たす肝星細胞に接する肝類洞内皮では、Gene Xが発現していた。このGene XはNAFLD/NASHの進行に伴って変化し、肝線維化の進行を抑制する効果があることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In the transition from simple fatty liver to non-alcoholic liver disease/hepatitis (NAFLD/NASH), it is known that metabolism is altered in each liver lobule zone (metabolic zonation). The present analysis revealed that the genes expressed in the cells constituting the liver change accordingly. Gene X was expressed in the hepatic sinusoidal endothelium bordering hepatic stellate cells, which play an important role in fibrosis. This Gene X changes with the progression of NAFLD/NASH, suggesting that Gene X has an inhibitory effect on the progression of liver fibrosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17H06393, 研究期間(年度):2017-06-30 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝硬変における炎症細胞社会の解明」課題番号17H06393\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PLANNED-17H06393/17H06393seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00060283","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60185923"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60185923","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-17H06393/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-17H06393/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PLANNED-17H06393/17H06393seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PLANNED-17H06393/17H06393seika/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-4901/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-AREA-4901/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-4901/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-4901/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 周一"}],"nameIdentifiers":[{"nameIdentifier":"68205","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60185923","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60185923"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-06-26"}],"displaytype":"detail","filename":"ME-PR-KANEKO-S-kaken 2022-16p.pdf","filesize":[{"value":"885.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KANEKO-S-kaken 2022-16p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/54005/files/ME-PR-KANEKO-S-kaken 2022-16p.pdf"},"version_id":"1a5803e1-ba82-431e-846f-d4fdf18bf76b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝硬変における炎症細胞社会の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝硬変における炎症細胞社会の解明"},{"subitem_title":"Elucidation of inflammation cellular society in liver cirrhosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-06-26"},"publish_date":"2023-06-26","publish_status":"0","recid":"54005","relation_version_is_last":true,"title":["肝硬変における炎症細胞社会の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:15:49.005123+00:00"}